| + |
GNGT1 | up-regulates 
binding
|
PIK3CA |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16537363 |
Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GNGT1 | up-regulates
binding
|
PI3K |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252686 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252687 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16537363 |
Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNGT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148601 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD3 | up-regulates
binding
|
GNGT1 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wnt signalling pathway, frizzled uses galphaq or galphai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNGT1 | up-regulates
binding
|
PLCG1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199144 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Furthermore, this work suggested that the gbetagamma subunits released upon gi activation activated phospholipase c-gamma (plc-gamma) to produce inositol 3 phosphate (ip3) which would subsequently increase intracellular ca2+ abundance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNGT1 | up-regulates
binding
|
PIK3CG |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96831 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12507995 |
Therefore, we conclude that in vivo, g beta gamma activates pi3k gamma by a mechanism assigning specific roles for both pi3k gamma subunits, i.e., membrane recruitment is mediated via the noncatalytic p101 subunit, and direct stimulation of g beta gamma with p110 gamma contributes to activation of pi3k gamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GNGT1
- 
- 