3.0
Summary
| Name |  CSNK1G2View Modifications |
| Full Name | Casein kinase I isoform gamma-2 |
| Synonyms | CKI-gamma 2 | CK1G2 |
| Primary ID | P78368 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK1G2 | up-regulates quantity by stabilization 
phosphorylation
|
LYN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1G2 | down-regulates 
phosphorylation
|
CERT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||
| + | CSNK1G2 | down-regulates
phosphorylation
|
SMAD3 | 0.342 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1G2 | down-regulates quantity by destabilization
phosphorylation
|
IRS4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1G2 | down-regulates
phosphorylation
|
PER1 | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |