+ |
PRKD1 | down-regulates
phosphorylation
|
CERT1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-156500 |
Ser132 |
SSLRRHGsMVSLVSG |
Homo sapiens |
|
pmid |
sentence |
17591919 |
In this study, we identify cert as a novel in vivo pkd substrate. Phosphorylation on serine 132 by pkd decreases the affinity of cert toward its lipid target phosphatidylinositol 4-phosphate at golgi membranes and reduces ceramide transfer activity |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CSNK1G2 | down-regulates
phosphorylation
|
CERT1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-182160 |
Ser132 |
SSLRRHGsMVSLVSG |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
19005213 |
These results indicate that ckigamma2 hyperphosphorylates the serine-repeat motif of cert, thereby inactivating cert and down-regulating the synthesis of sphingomyelin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Ovary |
+ |
CERT1 | up-regulates quantity
relocalization
|
ceramide |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268496 |
|
|
Homo sapiens |
|
pmid |
sentence |
18184806 |
In mammalian cells, ceramide is synthesized in the endoplasmic reticulum and transferred to the Golgi apparatus for conversion to sphingomyelin. Ceramide transport occurs in a nonvesicular manner and is mediated by CERT, a cytosolic 68-kDa protein with a C-terminal steroidogenic acute regulatory protein-related lipid transfer (START) domain. The CERT START domain efficiently transfers natural D-erythro-C16-ceramide, but not lipids with longer (C20) amide-acyl chains. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPM1L | up-regulates activity
dephosphorylation
|
CERT1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277113 |
|
|
Homo sapiens |
|
pmid |
sentence |
18165232 |
The expression of PP2Cepsilon also enhanced the association between CERT and VAPA.|These results suggest that CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |