| + |
MBD4 | up-regulates 
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275714 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275684 |
|
|
|
|
| pmid |
sentence |
| 23195996 |
The base excision repair DNA N-glycosylase MBD4 (also known as MED1), an interactor of the DNA mismatch repair protein MLH1, plays a central role in the maintenance of genomic stability of CpG sites by removing thymine and uracil from G:T and G:U mismatches, respectively. |
|
| Publications: |
2 |
| + |
NEIL2 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275719 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
NEIL3 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275720 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
APEX1 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275721 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
An essential role of BER has been documented by inactivating functions of proteins in the common steps of BER. Thus, the major AP-endonuclease in mammalian cells, APE1, is essential for survival, as shown using knockout mice (Friedberg and Meira 2006). APE1 (also called HAP1 and Apex) carries both an AP-endonuclease activity and a redox function required for activation of several transcription factors |
|
| Publications: |
1 |
| + |
SMUG1 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275712 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
MUTYH | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275716 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
TDG | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275713 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
NEIL1 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275718 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
UNG | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275711 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
NTHL1 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275717 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
| + |
OGG1 | up-regulates
|
Base-excision_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275715 |
|
|
|
|
| pmid |
sentence |
| 23545420 |
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1). |
|
| Publications: |
1 |
3.0
Base-excision_repair