4.0
Summary
| Name |  HSD11B2
|
| Full Name | Corticosteroid 11-beta-dehydrogenase isozyme 2 |
| Synonyms | 11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type II, 11-HSD type II, 11-beta-HSD type II, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, 11-beta-HSD, Short chain dehydrogenase/reductase family 9C member 3 | HSD11K, SDR9C3 |
| Primary ID | P80365 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPARD | down-regulates quantity by repression 
transcriptional regulation
|
HSD11B2 | 0.314 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
HSD11B2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EGR1 | down-regulates quantity by repression
transcriptional regulation
|
HSD11B2 | 0.277 |
| Publications: | 1 | Organism: | Homo Sapiens | |