| + |
PPARD | up-regulates quantity by expression 
transcriptional regulation
|
TXN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255052 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 18048767 |
Activation of PPAR-delta upregulated the expression of antioxidant genes superoxide dismutase 1, catalase, and thioredoxin and decreased reactive oxygen species production in ECs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide | down-regulates activity 
chemical inhibition
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262014 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 27489280 |
We performed reporter assays to examine the effect of NeoB on the transcriptional activity of specific nuclear hormone receptors, including PPARs, retinoic acid receptor (RAR), ER, and LXR, in uninfected Huh7-25 cells (Fig. 3A). NeoB did not have a significant effect [...] in contrast to the transcriptional repression by known antagonists as positive controls (GW6471, GSK0660, FH535, Ro41-5253, and 4-hydroxytamoxifen) (Fig. 3A) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
monoisononyl phthalate | up-regulates activity 
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268781 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
mono(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268746 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19433246 |
Phthalates are true ligands of PPARs. Mono-ethyl-hexyl-phthalate (MEHP), a metabolite of the widespread plasticizer di-ethyl-hexyl-phthalate (DEHP), has been found in exposed organisms and interacts with all three PPARs. A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268784 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| + |
PPARD | down-regulates quantity by repression 
transcriptional regulation
|
HSD11B2 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255050 |
|
|
Homo sapiens |
Placental Cell Line |
| pmid |
sentence |
| 15591138 |
Peroxisome proliferator-activated receptor delta suppresses 11beta-hydroxysteroid dehydrogenase type 2 gene expression in human placental trophoblast cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
perfluorodecanoic acid | up-regulates activity
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268758 |
|
|
in vitro |
|
| pmid |
sentence |
| 31332417 |
In the present study, we demonstrated PFASs bound to and activated human PPARb/d-LBD directly. The PPARb/d binding potency and transcriptional activity of PFASs were all related to the carbon chain length and the terminal functional group. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPARD | up-regulates quantity by expression
transcriptional regulation
|
CAT |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255051 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18048767 |
Activation of PPAR-delta upregulated the expression of antioxidant genes superoxide dismutase 1, catalase, and thioredoxin and decreased reactive oxygen species production in ECs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARD | up-regulates quantity by expression
transcriptional regulation
|
SOD1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255053 |
|
|
Homo sapiens |
HOS-TE85 Cell |
| pmid |
sentence |
| 18048767 |
Activation of PPAR-delta upregulated the expression of antioxidant genes superoxide dismutase 1, catalase, and thioredoxin and decreased reactive oxygen species production in ECs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
perfluorododecanoic acid | up-regulates activity
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268759 |
|
|
in vitro |
|
| pmid |
sentence |
| 31332417 |
In the present study, we demonstrated PFASs bound to and activated human PPARb/d-LBD directly. The PPARb/d binding potency and transcriptional activity of PFASs were all related to the carbon chain length and the terminal functional group. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RXRB | up-regulates
binding
|
PPARD |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
perfluorooctane-1-sulfonic acid | up-regulates activity
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268757 |
|
|
in vitro |
|
| pmid |
sentence |
| 31332417 |
In the present study, we demonstrated PFASs bound to and activated human PPARb/d-LBD directly. The PPARb/d binding potency and transcriptional activity of PFASs were all related to the carbon chain length and the terminal functional group. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
perfluorohexanesulfonic acid | up-regulates activity
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268755 |
|
|
in vitro |
|
| pmid |
sentence |
| 31332417 |
In the present study, we demonstrated PFASs bound to and activated human PPARb/d-LBD directly. The PPARb/d binding potency and transcriptional activity of PFASs were all related to the carbon chain length and the terminal functional group. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RXRA | up-regulates
binding
|
PPARD |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105442 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
perfluorononanoic acid | up-regulates activity
chemical activation
|
PPARD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268756 |
|
|
in vitro |
|
| pmid |
sentence |
| 31332417 |
In the present study, we demonstrated PFASs bound to and activated human PPARb/d-LBD directly. The PPARb/d binding potency and transcriptional activity of PFASs were all related to the carbon chain length and the terminal functional group. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPARD | up-regulates quantity by expression
transcriptional regulation
|
SLC25A20 |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255048 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19577614 |
CACT is upregulated by PPARalpha and PPARdelta, probably by binding to a functional PPRE at position +45 to +57 relative to the transcription start site. The upregulation of CACT by PPARalpha and PPARdelta, which are both important for the regulation of fatty acid oxidation in tissues during fasting, may increase the import of acylcarnitine into the mitochondrial matrix during fasting. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
PPARD
- 
- 