| + |
PPM1G | down-regulates quantity by destabilization 
dephosphorylation
|
USP7 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276531 |
Ser18 |
KAGEQQLsEPEDMEM |
|
|
| pmid |
sentence |
| 22361354 |
We find that stabilization of Mdm2, and correspondingly p53 downregulation in unstressed cells, is accomplished by a specific isoform of USP7 (USP7S), which is phosphorylated at serine 18 by the protein kinase CK2. |After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation of p53. |
|
| Publications: |
1 |
| + |
ATM | up-regulates activity 
phosphorylation
|
PPM1G |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255591 |
Ser183 |
GTGEEPGsQGLNGEA |
in vitro |
|
| pmid |
sentence |
| 26324325 |
ATM indeed mediated PPM1G phosphorylation at S183, and mutation of this residue (S183A) abrogated detection with the phospho-specific antibody |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPM1G | up-regulates activity
dephosphorylation
|
CDKN1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277112 |
Thr198 |
PGLRRRQt |
Homo sapiens |
|
| pmid |
sentence |
| 27822412 |
By using genomic phosphatase screening, we identified a PPM family phosphatase, PPM1G, which could reduce p27 phosphorylation at T198.|Functionally, ectopic expression of PPM1G enhanced p27 protein stability and delayed cell cycle progression from G1 to S phase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1G | up-regulates quantity by stabilization
dephosphorylation
|
SNRPN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277021 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17984321 |
Dephosphorylation of survival motor neurons (SMN) by PPM1G and PP2Cgamma governs Cajal body localization and stability of the SMN complex.|This indicates that the catalytic activity of PPM1G promotes accumulation of the SMN complex in CBs and suggests that PPM1G is a major determinant of the SMN-complex localization in the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1G | down-regulates activity
dephosphorylation
|
SRSF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34290239 |
Here, we found that the PPM1G regulated SRSF3, and high levels of PPM1G decreased SRSF3 activity in HCC cells.|PPM1G interacted with SRSF3 and dephosphorylated SRSF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1G | down-regulates activity
dephosphorylation
|
ATM |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361354 |
After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation of p53. |ATM Dependent Downregulation of USP7 and HAUSP by PPM1G Activates p53 Response to DNA Damage.|DNA Damage Leads to ATM Dependent USP7S Dephosphorylation by PPM1G. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1G | down-regulates activity
dephosphorylation
|
USP7 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361354 |
Here, we report that in response to DNA damage USP7 is downregulated by the ATM dependent protein phosphatase PPM1G, thus downregulating Mdm2 and activating the p53 response.|We have now shown that when DNA damage is detected, PPM1G is activated and dephosphorylates USP7 isoform protein that leads to its degradation and consequently to Mdm2 degradation and accumulation of p53 ( A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPM1G
- 
- 