3.0
Summary
| Name |  CLTCView Modifications |
| Full Name | Clathrin heavy chain 1 |
| Synonyms | Clathrin heavy chain on chromosome 17, CLH-17 | CLH17, CLTCL2, KIAA0034 |
| Primary ID | Q00610 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GAK | up-regulates activity 
phosphorylation
|
CLTC | 0.849 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | SRC | up-regulates
phosphorylation
|
CLTC | 0.419 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLTC | form complex 
binding
|
AP-2/clathrin vescicle | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLTC | form complex
binding
|
AP-3/clathrin vescicle | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLTC | form complex
binding
|
AP-1/clathrin vescicle | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATG16L1 | up-regulates
binding
|
CLTC | 0.477 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PICALM | up-regulates
binding
|
CLTC | 0.736 |
| Publications: | 1 | Organism: | Homo Sapiens | |