4.0
Summary
| Name |  CACNA1BView Modifications |
| Full Name | Voltage-dependent N-type calcium channel subunit alpha-1B |
| Synonyms | Brain calcium channel III, BIII, Calcium channel, L type, alpha-1 polypeptide isoform 5, Voltage-gated calcium channel subunit alpha Cav2.2 | CACH5, CACNL1A5 |
| Primary ID | Q00975 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | GABAergic synapse |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CAMK2A | down-regulates 
phosphorylation
|
CACNA1B | 0.316 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates activity 
phosphorylation
|
CACNA1B | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | GNB/GNG | down-regulates activity
binding
|
CACNA1B | 0.414 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | GABAergic synapse | |||
| + | ANK2 | up-regulates quantity
binding
|
CACNA1B | 0.263 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Brain | |||
| + | CACNA1B | up-regulates quantity
relocalization
|
calcium(2+) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | GABAergic synapse | |||