| + |
RNF128 | down-regulates quantity by destabilization 
polyubiquitination
|
CD83 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271850 |
Lys177 |
SIFPDFSkAGMERAF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19542455 |
In this study, we show that GRAIL can down-modulate the expression of CD83 (previously described as a cell surface marker for mature dendritic cells) on CD4 T cells. GRAIL-mediated down-modulation of CD83 is dependent on an intact GRAIL extracellular protease-associated domain and an enzymatically active cytosolic RING domain, and proceeds via the ubiquitin-dependent 26S proteosome pathway. Ubiquitin modification of lysine residues K168 and K183, but not K192, in the cytoplasmic domain of CD83 was shown to be necessary for GRAIL-mediated degradation of CD83. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271849 |
Lys192 |
LPVTSPNkHLGLVTP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19542455 |
In this study, we show that GRAIL can down-modulate the expression of CD83 (previously described as a cell surface marker for mature dendritic cells) on CD4 T cells. GRAIL-mediated down-modulation of CD83 is dependent on an intact GRAIL extracellular protease-associated domain and an enzymatically active cytosolic RING domain, and proceeds via the ubiquitin-dependent 26S proteosome pathway. Ubiquitin modification of lysine residues K168 and K183, but not K192, in the cytoplasmic domain of CD83 was shown to be necessary for GRAIL-mediated degradation of CD83. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
CD83 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19164127 |
We found that upon TLR7 and TLR8 activation, JNK and NF-kappaB positively regulated the expression of CCR7, CD86, CD83, and CD40 and the production of IL-6 and IL-12p40. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CD83
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