Name	RNF128 View Modifications
Full Name	E3 ubiquitin-protein ligase RNF128
Synonyms	Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RING-type E3 ubiquitin transferase RNF128 \|
Primary ID	Q8TEB7
Links	- -
Type	protein
Relations	5
Function	E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.