Summary

Name HMGCS1
Full Name Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Synonyms HMG-CoA synthase, EC 2.3.3.10, 3-hydroxy-3-methylglutaryl coenzyme A synthase | HMGCS
Primary ID Q01581
Links - -
Type protein
Relations 2
Pathways Ferroptosis in PDAC
Function Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HMGCS1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Ferroptosis
Publications: 1 Organism: Homo Sapiens