| + |
HIF1A | up-regulates quantity by expression 
transcriptional regulation
|
P4HA1 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279840 |
|
|
Homo sapiens |
Pancreatic Ductal Adenocarcinoma Cell |
| pmid |
sentence |
| 40332386 |
Hypoxia upregulates P4HA1 expression in PDAC PDOs through HIF1α. Our results show that the treatment of PDO4 and PDO11 cells with 10 μmol/L of PX-478 for 24 hours reduced the levels of P4HA1 in hypoxia (Fig. 2F), suggesting P4HA1 expression in hypoxia is regulated by HIF1α expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
P4HA1 | up-regulates 
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279876 |
|
|
|
|
| pmid |
sentence |
| 31239153 |
Subsequent functional experiments confirmed our conclusions that P4HA1 is a crucial regulator of PDAC glycolysis. Therefore, our findings uncovered a previous unprecedented role of P4HA1 in cancers. Increased glycolysis provides cancer cells with abundant cellular buildings and reducing substrate, which are needed for rapid cell proliferation |
|
| Publications: |
1 |
| + |
P4HA1 | up-regulates quantity
chemical modification
|
Collagen |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279877 |
|
|
Homo sapiens |
Pancreatic Ductal Adenocarcinoma Cell |
| pmid |
sentence |
| 40332386 |
P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids.Collagen prolyl 4-hydroxylase subunit alpha-1 (P4HA1) is the most common isoform of the collagen prolyl 4-hydroxylases and contributes to collagen synthesis and deposition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
P4HA1 | up-regulates quantity by expression
transcriptional regulation
|
HMGCS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279853 |
|
|
Homo sapiens |
Nasopharyngeal Carcinoma Cell |
| pmid |
sentence |
| 36702290 |
In this study, we found that the prolyl 4-hydroxylase (P4H) subunit P4HA1 protects NPC cells from erastin-induced ferroptosis by activating HMGCS1, a key enzyme in the mevalonate pathway. Our results show that HMGCS1 and HMGCR are regulated by P4HA subunits at the transcriptional level (Fig. S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
P4HA1 | up-regulates activity
|
HIF1A |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279875 |
|
|
|
|
| pmid |
sentence |
| 31239153 |
P4HA1 regulates HIF1a activity in pancreatic cancer. P4HA1 can also increase HIF1a protein level in PDAC cells indicative of a positive feedback loop between P4HA1 and HIF1a. |
|
| Publications: |
1 |
| + |
P4HA1 | up-regulates quantity by expression
transcriptional regulation
|
HMGCR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279854 |
|
|
Homo sapiens |
Nasopharyngeal Carcinoma Cell |
| pmid |
sentence |
| 36702290 |
In this study, we found that the prolyl 4-hydroxylase (P4H) subunit P4HA1 protects NPC cells from erastin-induced ferroptosis by activating HMGCS1, a key enzyme in the mevalonate pathway. Our results show that HMGCS1 and HMGCR are regulated by P4HA subunits at the transcriptional level (Fig. S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
P4HA1
- 
- 