Summary

Name APBA1
Full Name Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms Adapter protein X11alpha, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1, Mint-1 | MINT1, X11
Primary ID Q02410
Links - -
Type protein
Relations 4
Pathways Neurotransmitters release
Function Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ APBA1up-regulates activity img/direct-activation.png binding CASK 0.845
Publications: 1 Organism: Chlorocebus Aethiops
+ APBA1up-regulates activity img/direct-activation.png binding NRXN1 0.651
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Neurotransmitters release
+ APBA1up-regulates activity img/direct-activation.png binding STXBP1 0.688
Publications: 1 Organism: Rattus Norvegicus
Pathways:Neurotransmitters release
+ APBA1up-regulates img/indirect-activation.png Exocytosis 0.7
Publications: 1 Organism: Homo Sapiens