3.0
Summary
| Name |  KMT2AView Modifications |
| Full Name | Histone-lysine N-methyltransferase 2A |
| Synonyms | Lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7, Myeloid/lymphoid or mixed-lineage leukemia, Myeloid/lymphoid or mixed-lineage leukemia protein 1, Trithorax-like protein, Zinc finger protein HRX | ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1 |
| Primary ID | Q03164 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Pathways | HaematopoiesisTranscriptionalControl |
| Function | Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATR | up-regulates 
phosphorylation
|
KMT2A | 0.284 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2A | form complex 
binding
|
MLL1 complex | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2A | up-regulates quantity by stabilization
binding
|
RUNX1 | 0.549 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | KMT2A | up-regulates 
|
Epigenetic_regulation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAX7 | up-regulates
binding
|
KMT2A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2A | up-regulates quantity by expression
methylation
|
SPI1 | 0.417 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | MEN1 | up-regulates activity
binding
|
KMT2A | 0.718 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KMT2A | up-regulates
binding
|
KAT8 | 0.465 |
| Publications: | 1 | Organism: | Homo Sapiens | |