Summary

Name KMT2A
Full Name Histone-lysine N-methyltransferase 2A
Synonyms Lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7, Myeloid/lymphoid or mixed-lineage leukemia, Myeloid/lymphoid or mixed-lineage leukemia protein 1, Trithorax-like protein, Zinc finger protein HRX | ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
Primary ID Q03164
Links - -
Type protein
Relations 9
Pathways HaematopoiesisTranscriptionalControl
Function Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation KMT2A 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding KMT2A 0.72
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding RUNX1 0.551
Publications: 2 Organism: Homo Sapiens
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates img/direct-activation.png binding KMT2A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png methylation SPI1 0.418
Publications: 1 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ form complex img/form-complex.png binding MLL1 complex 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding KAT8 0.467
Publications: 1 Organism: Homo Sapiens