| + |
9-cis-retinoic acid | up-regulates activity 
chemical activation
|
RXRB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates quantity by expression 
transcriptional regulation
|
RARB |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
NR1H2 |
0.681 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123094 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14993927 |
We provide genetic and molecular evidence that cholesterol homeostasis in scs does not require pparalpha and beta, but depends upon the tif2 coactivator and rxrbeta/lxrbeta heterodimers, in which rxrbeta af-2 is transcriptionally active. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
THRB |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
NR2F2 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10900149 |
Arp-1/rxr, coup-tfi/rxr, and arp-1/coup-tfi heterodimers bound the fp330-3' site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
THR |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269880 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270297 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates
binding
|
RXRB |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARB | up-regulates
binding
|
RXRB |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16581 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
NR4A2 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58309 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 9636132 |
The recent discovery that the nuclear transcription factor, nurr1, in heterodimeric tandem with rxr, is unequivocally necessary for the expression of dopaminergic neurons |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
NR2F1 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10900149 |
Arp-1/rxr, coup-tfi/rxr, and arp-1/coup-tfi heterodimers bound the fp330-3' site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
RARB |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
RARG |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
RAR |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269852 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
RARA |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
PPARG |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78907 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10882139 |
The nuclear receptor ppargamma/rxralpha heterodimer regulates glucose and lipid homeostasis |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
bexarotene | up-regulates activity
chemical activation
|
RXRB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259231 |
|
|
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 17483357 |
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
all-trans-retinoic acid | up-regulates activity
chemical activation
|
RXRB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256191 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17132853 |
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
PPARD |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
NRIP1 |
0.585 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12403842 |
Receptor interacting protein 140 (rip140) is a coregulator for a large number of transcription factors. Rip140 interacts with retinoic acid receptor (rar) and retinoid x receptor (rxr) with or without ligands |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
THRA |
0.636 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
PPARA |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates activity
binding
|
THR |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267805 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RXRB
- 
- 