| + |
MAPK3 | down-regulates activity 
phosphorylation
|
RXRA |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88662 |
Ser260 |
NMGLNPSsPNDPVTN |
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262959 |
Thr82 |
HSMSVPTtPTLGFST |
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates activity
phosphorylation
|
RXRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244573 |
Ser260 |
NMGLNPSsPNDPVTN |
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262960 |
Thr82 |
HSMSVPTtPTLGFST |
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MAPK8 | down-regulates activity
phosphorylation
|
RXRA |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145297 |
Ser260 |
NMGLNPSsPNDPVTN |
Homo sapiens |
|
| pmid |
sentence |
| 16551633 |
Under stress conditions, hyperphosphorylated by activated jnk on ser-56, ser-70, thr-82 and ser-260. These findings indicate that inflammation-mediated cell signaling leads to rapid and profound reductions in nuclear rxralpha levels, via a multistep, jnk-dependent mechanism involving ser260, nuclear export, and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MAPK9 | down-regulates activity
phosphorylation
|
RXRA |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145301 |
Ser260 |
NMGLNPSsPNDPVTN |
Homo sapiens |
|
| pmid |
sentence |
| 16551633 |
Under stress conditions, hyperphosphorylated by activated jnk on ser-56, ser-70, thr-82 and ser-260. These findings indicate that inflammation-mediated cell signaling leads to rapid and profound reductions in nuclear rxralpha levels, via a multistep, jnk-dependent mechanism involving ser260, nuclear export, and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates activity
phosphorylation
|
RXRA |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88658 |
Ser260 |
NMGLNPSsPNDPVTN |
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262958 |
Thr82 |
HSMSVPTtPTLGFST |
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
RXRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104954 |
Ser27 |
TSPTGRGsMAAPSLH |
Homo sapiens |
|
| pmid |
sentence |
| 11162439 |
Serine 27, a human retinoid x receptor alpha residue, phosphorylated by protein kinase a is essential for cyclicamp-mediated downregulation of rxralpha function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates activity 
phosphorylation
|
RXRA |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277372 |
Ser49 |
GSPGQLHsPISTLSS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29137318 |
GSK3β-induced RXRα phosphorylation decreased for RXRα-S49A, RXRα-S66A and RXRα-S78A in HEK293 cells compared with RXRα WT by western blot analysis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277370 |
Ser66 |
NGMGPPFsVISSPMG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29137318 |
GSK3β-induced RXRα phosphorylation decreased for RXRα-S49A, RXRα-S66A and RXRα-S78A in HEK293 cells compared with RXRα WT by western blot analysis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277371 |
Ser78 |
PMGPHSMsVPTTPTL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29137318 |
GSK3β-induced RXRα phosphorylation decreased for RXRα-S49A, RXRα-S66A and RXRα-S78A in HEK293 cells compared with RXRα WT by western blot analysis. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MAP2K4 | down-regulates
phosphorylation
|
RXRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80619 |
Tyr249 |
VEPKTETyVEANMGL |
Homo sapiens |
|
| pmid |
sentence |
| 10938283 |
Phosphorylation by mkk4/sek1 had profound effects on the biochemical properties of rxr, inhibiting the expression of genes activated by rxr-retinoic acid receptor complexes. Tyr-249 in the rxr de region was required for the inhibitory effect of mkk4/sek1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1I2 | up-regulates
binding
|
RXRA |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111624 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11706036 |
The constitutive androstane receptor (car, nr1i4), like fxr and pxr, binds dna as a heterodimer with rxr? |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
RARG |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16671 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
ASXL1 | up-regulates activity
binding
|
RXRA |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255911 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16606617 |
In this study, we demonstrate that mammalian ASXL1 interacts with the AF-2 AD core of RAR (and RXR) through a novel, promiscuous NR box (LVMQLL) and enhances transcriptional activity of the receptors in certain cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
| + |
RXRA | up-regulates
binding
|
NR1H2 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123091 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14993927 |
We provide genetic and molecular evidence that cholesterol homeostasis in scs does not require pparalpha and beta, but depends upon the tif2 coactivator and rxrbeta/lxrbeta heterodimers, in which rxrbeta af-2 is transcriptionally active. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARA | up-regulates
binding
|
RXRA |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling |
| + |
bexarotene | up-regulates activity
chemical activation
|
RXRA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259230 |
|
|
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 17483357 |
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
9-cis-retinoic acid | up-regulates activity
chemical activation
|
RXRA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates activity
binding
|
PML-RARalpha |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255804 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17613434 |
RXR Binding Increases the DNA-Binding Affinity of PML/RARA. Here, we demonstrate that the presence of the RARA heterodimeric partner RXR in the PML/RARA complex is required for leukemogenesis in transgenic mice. RXR greatly facilitates the binding of PML/RARA to DNA, but titration of RXR by PML/RARA could also contribute to transformation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia |
| + |
RXRA | up-regulates
binding
|
PPARA |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105345 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA2 | up-regulates
binding
|
RXRA |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114847 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11851396 |
Here, it is demonstrated that mutation of the h11 phenylalanine residues diminishes the ability of rxr to associate with the p160 coactivators tif2 and p/cip, but has little effect on ligand-dependent interactions of the receptor with the unrelated coactivator tif1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
THR |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269877 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates quantity by expression 
transcriptional regulation
|
CPT1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254582 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15356291 |
Mutation analysis indicated that the MEF2 site contributed to the activation of the CPT1beta promoter by PPAR in C2C12 cells. The reporter construct containing the PPRE and the MEF2C site was synergistically activated by co-expression of PPAR, retinoid X receptor (RXR) and MEF2C in non-muscle cells. Moreover, protein-binding assays demonstrated that MEF2C and PPAR specifically bound to one another in vitro. Also for the synergistic activation of the CPT1beta gene promoter by MEF2C and PPARalpha-RXRalpha, a precise arrangement of its binding sites was essential. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NR2F1 | up-regulates
binding
|
RXRA |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79440 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10900149 |
Arp-1/rxr, coup-tfi/rxr, and arp-1/coup-tfi heterodimers bound the fp330-3' site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAR | up-regulates
binding
|
RXRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | down-regulates
binding
|
CTNNB1 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12771132 |
Rxr agonists still inactivated endogenous beta-catenin via rxr alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling |
| + |
RXRA | up-regulates
binding
|
RARA |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling |
| + |
RXRA | up-regulates
binding
|
THRA |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
THRB |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
RXRA |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12573484 |
Physiological concentrations of glucocorticoids increase cellular cyp2c9 (and cyp3a5) but also car, rxr and pxr levels via a gr-mediated mechanism |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1I3 | up-regulates
binding
|
RXRA |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104441 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12896978 |
Therefore, both car-rxr heterodimers and car monomers can contribute to the gene activating function of pbrems in car target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
PPARD |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105442 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
RAR |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates activity
binding
|
THR |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267800 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10976919 |
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sulindac | down-regulates activity
chemical inhibition
|
RXRA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257847 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 20541701 |
NSAID Sulindac and Its Analogs Bind RXRα and Inhibit RXRα-dependent AKT Signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
[5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid | down-regulates activity
chemical inhibition
|
RXRA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20541701 |
NSAID Sulindac and Its Analogs Bind RXRα and Inhibit RXRα-dependent AKT Signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARB | up-regulates
binding
|
RXRA |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
RXRA | up-regulates
binding
|
RARB |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
NR2F2 | up-regulates
binding
|
RXRA |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10900149 |
Arp-1/rxr, coup-tfi/rxr, and arp-1/coup-tfi heterodimers bound the fp330-3' site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates
binding
|
RXRA |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16659 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
Gbeta | down-regulates activity
phosphorylation
|
RXRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17604322 |
In colon cancer cells, the Ras/mitogen‚Äêactivated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‚Äêmutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
PPARG |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RXRA
- 
- 