Relation Results

Summary

Name COL10A1
Full Name Collagen alpha-1
Synonyms COAA1_HUMAN |
Primary ID Q03692
Links - -
Type protein
Relations 2
Function Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

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Type: Score: Layout: SPV 
0.20.2EGR1COL10A1SIRT1

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Relations
Regulator
Mechanism
target
score ℹ
+ EGR1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL10A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251921 Homo sapiens
pmid sentence
Egr-1 induced a time-dependent ECM gene expression program, with the number of ECM genes increasing >2.5-fold (from 16 to 41) between 24 and 48 h. Genes in this group include those coding for multiple collagens (COL4A1, COL4A2, COL11A1, COL7A1, COL10A1)
Publications: 1 Organism: Homo Sapiens
+ SIRT1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COL10A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255141 Homo sapiens
pmid sentence
The inhibition of SIRT1 by siRNA induced OA-like gene expression changes, namely the significant down-regulation of aggrecan and up-regulation of COL10A1 and ADAMTS-5.
Publications: 1 Organism: Homo Sapiens
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