Summary

Name TLE4
Full Name Transducin-like enhancer protein 4
Synonyms Grg-4, Groucho-related protein 4 | GRG4, KIAA1261
Primary ID Q04727
Links - -
Type protein
Relations 4
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ PAX5down-regulates activity img/direct_inhibition.png binding TLE4 0.581
Publications: 1 Organism: Homo Sapiens
+ TLE4form complex img/form-complex.png binding PAX2/TLE4 0.469
Publications: 1 Organism: Homo Sapiens
Pathways:Focal segmental glomerulosclerosis
+ TLE4down-regulates activity img/direct_inhibition.png binding PAX2 0.469
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
Pathways:Focal segmental glomerulosclerosis
+ PHF12up-regulates activity img/direct-activation.png binding TLE4 0.2
Publications: 1 Organism: Homo Sapiens