| + |
PAX2 | up-regulates quantity by expression 
transcriptional regulation
|
WT1 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252290 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16631587 |
Cotransfection of Pax2 with the Wt1 reporter construct led to moderate activation of the Wt1 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
TLE4 | down-regulates activity 
binding
|
PAX2 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251710 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25631048 |
In cell culture, Grg4 suppresses Pax2-mediated transcriptional activation and inhibits phosphorylation of the Pax2 activation domain by WNT signaling and JNK |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293 Cell |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PAXIP1 | up-regulates activity
binding
|
PAX2 |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236965 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10908331 |
PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. The degree of interaction with the Pax2 C-terminal polypeptides correlates with their transcription transactivation potential and we have therefore designated this factor PTIP for Pax transactivation-domain interacting protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251711 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17925232 |
PTIP promotes assembly of the ALR complex and H3K4 methylation at a PAX2-binding DNA element. Without PTIP, Pax2 binds to this element but does not assemble the ALR complex |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
HEK-293 Cell |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
PAX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251712 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25631048 |
PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293 Cell |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
ROS | up-regulates quantity by expression 
|
PAX2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252295 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16985513 |
High glucose-induced Pax-2 gene expression is mediated, at least in part, via ROS generation and activation of the nuclear factor kappa B signaling pathway, but not via protein kinase C, p38 mitogen-activated protein kinase (MAPK), and p44/42 MAPK signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PAX2 | form complex 
binding
|
PAX2/TLE4 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256359 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16631587 |
Several Pax proteins are able to interact with groucho (TLE) family members. Recruitment of the groucho-related protein TLE4 may be involved in converting Pax2 into a transcriptional repressor of Wt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PAX2 | up-regulates activity
|
Urogenital_tract |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252301 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8575306 |
Pax-2 is required for multiple steps during the differentiation of intermediate mesoderm. In addition, Pax-2 mouse mutants provide an animal model for human hereditary kidney diseases. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
AGTR1 | up-regulates quantity by expression
transcriptional regulation
|
PAX2 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252294 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15569307 |
Ang II up-regulated Pax-2 gene expression via AT2R in IRPTC (immortalized rat renal proximal tubular cells) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
WT1 | down-regulates quantity by repression
transcriptional regulation
|
PAX2 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252298 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7720589 |
A marked increase in WT1 protein levels coincided precisely with down-regulation of the Pax-2 gene in the individual precursor cells of the visceral glomerular epithelium, suggesting a direct effect of the WT1 repressor protein on Pax-2 regulatory elements. To examine whether WT1 could directly repress Pax-2 transcription, binding of WT1 to three high affinity sites in the 5' untranslated Pax-2 leader sequence was demonstrated by DNAseI footprinting analysis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Kidney |
| Pathways: | Focal segmental glomerulosclerosis |
3.0
PAX2
- 
- 