4.0
Summary
| Name |  PDE4BView Modifications |
| Full Name | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| Synonyms | DPDE4, PDE32 | DPDE4 |
| Primary ID | Q07343 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Inhibitors | GSK256066 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PKA | up-regulates activity 
phosphorylation
|
PDE4B | 0.2 |
| Publications: | 2 | Organism: | Chlorocebus Aethiops | |
| + | MAPK1 | up-regulates activity
phosphorylation
|
PDE4B (isoform 2) | 0.268 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PRKACA | up-regulates activity
phosphorylation
|
PDE4B | 0.605 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | MAPK1 | up-regulates activity
phosphorylation
|
PDE4B | 0.268 |
| Publications: | 1 | Organism: | In Vitro | |
| + | GSK256066 | down-regulates 
chemical inhibition
|
PDE4B | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |