| + |
ABCC8 | form complex 
binding
|
KATP channel |
0.646 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28842488 |
ATP-sensitive K+ (KATP) channels, found throughout the body, are generated as octameric complexes consisting of four pore-forming Kir6.1 or Kir6.2 subunits with four regulatory sulfonylurea receptor (SUR1 or SUR2) subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates quantity 
binding
|
ABCC8 |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21478675 |
The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKA | down-regulates activity 
phosphorylation
|
ABCC8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278146 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 35065096 |
Activated PKA and EPAC enhance insulin granular exocytosis by insulin granular priming and phosphorylates sulfonylurea receptor (SUR1) KATP channel subunit and thereby closes KATP-channels in the plasma membrane [13,43,82], leading to membrane depolarization, and opening of the voltage gated Ca2+-channels. This leads to an increased influx of extracellular Ca2+, which triggers fusion of intracellular insulin-containing granules with the plasma membrane and thereby insulin secretion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278147 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 35065096 |
Activated PKA and EPAC enhance insulin granular exocytosis by insulin granular priming and phosphorylates sulfonylurea receptor (SUR1) KATP channel subunit and thereby closes KATP-channels in the plasma membrane [13,43,82], leading to membrane depolarization, and opening of the voltage gated Ca2+-channels. This leads to an increased influx of extracellular Ca2+, which triggers fusion of intracellular insulin-containing granules with the plasma membrane and thereby insulin secretion. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
ABCC8
- 
- 