| + |
RAPGEF4 | up-regulates quantity 
relocalization
|
INS |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278140 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 24843404 |
Activation of EPAC2 has recently been shown to increase the density of insulin‐containing granules near the plasma membrane, facilitating insulin secretion from the β cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1A |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263954 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10777494 |
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
3',5'-cyclic AMP | up-regulates activity
binding
|
RAPGEF4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278139 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 24843404 |
Both GIP and GLP‐1 exert their insulinotropic effects by binding to GIP and GLP‐1 receptors expressed on pancreatic β cells. Incretin‐bound receptors increase intracellular cAMP levels thereby activating protein kinase A (PKA)65 and exchange protein activated by cAMP2 (EPAC2)/cAMP‐guanine nucleotide exchange factor (GEF) II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates quantity
binding
|
RAP1A |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278143 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 21478675 |
The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates quantity
binding
|
ABCC8 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21478675 |
The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1B |
0.811 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263955 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10777494 |
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
RAPGEF4
- 
- 