Relation Results

Summary

Name RAPGEF4
Full Name Rap guanine nucleotide exchange factor 4
Synonyms Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, EPAC 2, cAMP-regulated guanine nucleotide exchange factor II, cAMP-GEFII | CGEF2, EPAC2
Primary ID Q8WZA2
Links - -
Type protein
Relations 6
Pathways GLP-1 and GIP receptor signaling in PDAC
Function Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Invo ...
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Type: Score: Layout: SPV 
0.3840.7890.8070.80.708RAPGEF4INSRAP1ARAP1B3',5'-cyclic AMPABCC8

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Relations
Regulator
Mechanism
target
score ℹ
+ RAPGEF4up-regulates quantity img/direct-activation.png relocalization INS 0.384
Identifier Residue Sequence Organism Cell Line
SIGNOR-278140 Homo sapiens Pancreatic Beta Cell
pmid sentence
Activation of EPAC2 has recently been shown to increase the density of insulin‐containing granules near the plasma membrane, facilitating insulin secretion from the β cells
Publications: 1 Organism: Homo Sapiens
+ RAPGEF4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAP1A 0.789
Identifier Residue Sequence Organism Cell Line
SIGNOR-263954 Chlorocebus aethiops COS-7 Cell
pmid sentence
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well.
Publications: 1 Organism: Chlorocebus Aethiops
+ RAPGEF4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAP1B 0.807
Identifier Residue Sequence Organism Cell Line
SIGNOR-263955 Chlorocebus aethiops COS-7 Cell
pmid sentence
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well.
Publications: 1 Organism: Chlorocebus Aethiops
+ 3',5'-cyclic AMPup-regulates activity img/direct-activation.png binding RAPGEF4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-278139 Homo sapiens Pancreatic Beta Cell
pmid sentence
Both GIP and GLP‐1 exert their insulinotropic effects by binding to GIP and GLP‐1 receptors expressed on pancreatic β cells. Incretin‐bound receptors increase intracellular cAMP levels thereby activating protein kinase A (PKA)65 and exchange protein activated by cAMP2 (EPAC2)/cAMP‐guanine nucleotide exchange factor (GEF) II
Publications: 1 Organism: Homo Sapiens
+ RAPGEF4up-regulates quantity img/direct-activation.png binding RAP1A 0.789
Identifier Residue Sequence Organism Cell Line
SIGNOR-278143 Homo sapiens Pancreatic Beta Cell
pmid sentence
 The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε.
Publications: 1 Organism: Homo Sapiens
+ RAPGEF4up-regulates quantity img/direct-activation.png binding ABCC8 0.708
Identifier Residue Sequence Organism Cell Line
SIGNOR-278141 Homo sapiens
pmid sentence
 The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε.
Publications: 1 Organism: Homo Sapiens
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