| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
HYAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253880 |
|
|
Homo sapiens |
253J Cell |
| pmid |
sentence |
| 18718911 |
In 253J-Lung and HT1376 bladder cancer cell lines, which show high HYAL-1 expression, transcription factors Egr-1, AP-2, and NFκB bind the HYAL-1 promoter. Because both SP1 and Egr-1 have two overlapping binding sites within the promoter (Fig. 5), it appears that although SP1 binding to the methylated HYAL-1 promoter turns off transcription, binding of Erg-1 (and also AP-2) to the unmethylated promoter turns on transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
HYAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253878 |
|
|
Homo sapiens |
253J Cell |
| pmid |
sentence |
| 18718911 |
In 253J-Lung and HT1376 bladder cancer cell lines, which show high HYAL-1 expression, transcription factors Egr-1, AP-2, and NFκB bind the HYAL-1 promoter. Because both SP1 and Egr-1 have two overlapping binding sites within the promoter (Fig. 5), it appears that although SP1 binding to the methylated HYAL-1 promoter turns off transcription, binding of Erg-1 (and also AP-2) to the unmethylated promoter turns on transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | down-regulates quantity by repression 
transcriptional regulation
|
HYAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253879 |
|
|
Homo sapiens |
253J Cell |
| pmid |
sentence |
| 18718911 |
in cells which do not express HYAL-1, we found SP1 binding to the HYAL-1 promoter. Because both SP1 and Egr-1 have two overlapping binding sites within the promoter (Fig. 5), it appears that although SP1 binding to the methylated HYAL-1 promoter turns off transcription, binding of Erg-1 (and also AP-2) to the unmethylated promoter turns on transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HYAL1
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