3.0
Summary
| Name |  CNTN1
|
| Full Name | Contactin-1 |
| Synonyms | Glycoprotein gp135, Neural cell surface protein F3 | |
| Primary ID | Q12860 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). |
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relocalization