Summary

Name DLG1
Full Name Disks large homolog 1
Synonyms Synapse-associated protein 97, SAP-97, SAP97, hDlg
Primary ID Q12959
Links - -
Type protein
Relations 9
Function Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DLG1 0.283
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DLG1 0.394
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DLG1 0.648
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation ZAP70 0.528
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Scribble_complex_DLG1-LLGL1_variant 0.542
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization DLG1 0.474
Publications: 1 Organism: Canis Lupus Familiaris
+ up-regulates activity img/direct-activation.png binding p38 0.636
Publications: 1 Organism: Homo Sapiens