Summary

Name ZAP70
Full Name Tyrosine-protein kinase ZAP-70
Synonyms 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase | SRK
Primary ID P43403
Links - -
Type protein
Relations 61
Pathways Mitochondrial dynamics in T cell exhaustion, P38 Signaling, T cell activation
Function Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation ZAP70 0.473
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation LCP2 0.805
Publications: 7 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation LCP2 0.805
Publications: 3 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MUC1 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZAP70 0.2
Publications: 6 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation LAT 0.77
Publications: 7 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation DUSP3 0.535
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation DUSP3 0.535
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ZAP70 0.615
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates img/direct-activation.png phosphorylation SH2B3 0.364
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation ZAP70 0.261
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation, binding ZAP70 0.615
Publications: 8 Organism: Mus Musculus, In Vitro, Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.473
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation DBNL 0.638
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.675
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZAP70 0.527
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ZAP70 0.704
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ZAP70 0.704
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB2 0.463
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.838
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation VAV1 0.838
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.694
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding ZAP70 0.286
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png binding ZAP70 0.366
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding ZAP70 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ZAP70 0.584
Publications: 1 Organism: Homo Sapiens