Summary

Name ZAP70
Full Name Tyrosine-protein kinase ZAP-70
Synonyms 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase | SRK
Primary ID P43403
Links - -
Type protein
Relations 50
Pathways P38 Signaling, T cell activation
Function Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation LCP2 0.7
Publications: 3 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation LCP2 0.7
Publications: 7 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MUC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZAP70 0.33
Publications: 6 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates img/direct-activation.png phosphorylation DUSP3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LAT 0.69
Publications: 5 Organism: Homo Sapiens
Pathways:T cell activation
+ img/unknown.png phosphorylation ZAP70 0.75
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ up-regulates img/direct-activation.png phosphorylation SH2B3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation ZAP70 0.14
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation, binding ZAP70 0.63
Publications: 7 Organism: Mus Musculus, Homo Sapiens, In Vitro
Pathways:P38 Signaling, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation DBNL 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.31
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ZAP70 0.75
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, T cell activation
+ down-regulates img/direct_inhibition.png dephosphorylation ZAP70 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ZAP70 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZAP70 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation ZAP70 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png binding ZAP70 0.14
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding ZAP70 0.38
Publications: 1 Organism: Homo Sapiens