Summary

Name MAP2K5
Full Name Dual specificity mitogen-activated protein kinase kinase 5
Synonyms MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5 | MEK5, MKK5, PRKMK5
Primary ID Q13163
Links - -
Type protein
Relations 16
Inhibitors 3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide; SL-327; BIX-02188
Function Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MAP2K5 0.38
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation MAPK7
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation MAPK7 0.55
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation MAP2K5 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2K5 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAP2K5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAP2K5 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K5 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition MAP2K5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAP2K5 0.28
Publications: 1 Organism: Homo Sapiens