| + |
SGK1 | down-regulates activity 
phosphorylation
|
MAP3K3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101211 |
Ser166 |
EPRSRHLsVSSQNPG |
Homo sapiens |
|
| pmid |
sentence |
| 12761204 |
Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250004 |
Ser166 |
EPRSRHLsVSSQNPG |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 12392720 |
It was shown that the recombinant MEKK3 protein and fluorescein-labeled MEKK3 peptides (FITC-(159)epRsRhlSVi(168) and FITC-(330)dpRgRlpSAd(339)) are phosphorylated by SGK1 in vitro. It was also observed that the intrinsic kinase activity of MEKK3 on Ser(189) of MKK3 (equivalent to Ser(207) of MKK6) decreased along with phosphorylation of Ser(166) and Ser(337) in MEKK3 in vitro and in vivo. Therefore, it is suggested that SGK1 inhibits MEKK3-MKK3/6 signal transduction by phosphorylation of MEKK3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250005 |
Ser337 |
DPRGRLRsADSENAL |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 12392720 |
It was shown that the recombinant MEKK3 protein and fluorescein-labeled MEKK3 peptides (FITC-(159)epRsRhlSVi(168) and FITC-(330)dpRgRlpSAd(339)) are phosphorylated by SGK1 in vitro. It was also observed that the intrinsic kinase activity of MEKK3 on Ser(189) of MKK3 (equivalent to Ser(207) of MKK6) decreased along with phosphorylation of Ser(166) and Ser(337) in MEKK3 in vitro and in vivo. Therefore, it is suggested that SGK1 inhibits MEKK3-MKK3/6 signal transduction by phosphorylation of MEKK3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101216 |
Ser337 |
DPRGRLRsADSENAL |
Homo sapiens |
|
| pmid |
sentence |
| 12761205 |
Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 2 |
|
| Publications: |
4 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| + |
MAP3K3 | up-regulates 
phosphorylation
|
RCAN1 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102294 |
Ser167 |
FLISPPAsPPVGWKQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12809556 |
Essential role of mekk3 signaling in angiotensin ii-induced calcineurin/nuclear factor of activated t-cells activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138945 |
Ser167 |
FLISPPAsPPVGWKQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 16126726 |
Essential role of mekk3 signaling in angiotensin ii-induced calcineurin/nuclear factor of activated t-cells activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates activity
phosphorylation
|
IKBKB |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279467 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 14636585 |
Genetic analysis showed that MEKK3, which is thought to activate IKK2 through phosphorylation (Yang et al., 2001), is necessary for TNF-alpha-induced NF-kappaB activation.|Our results also suggest that IKK2 is phosphorylated on S177 and S181 on its activation loop by MEKK3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279468 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 14636585 |
Genetic analysis showed that MEKK3, which is thought to activate IKK2 through phosphorylation (Yang et al., 2001), is necessary for TNF-alpha-induced NF-kappaB activation.|Our results also suggest that IKK2 is phosphorylated on S177 and S181 on its activation loop by MEKK3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48625 |
Ser218 |
ISGYLVDsVAKTMDA |
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 9162092 |
These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates activity
phosphorylation
|
SQSTM1 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279533 |
Ser272 |
RSRLTPVsPESSSTE |
Homo sapiens |
|
| pmid |
sentence |
| 26279575 |
MEKK3 overexpression, but not that of a kinase dead mutant, was able to induce the phosphorylation of p62 at T269 and S272 (XREF_FIG), which correlated with mTORC1 activation (XREF_FIG), suggesting that MEKK3 could be a bona fide regulator of p62 phosphorylation and mTORC1 activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279532 |
Thr269 |
GGKRSRLtPVSPESS |
Homo sapiens |
|
| pmid |
sentence |
| 26279575 |
MEKK3 overexpression, but not that of a kinase dead mutant, was able to induce the phosphorylation of p62 at T269 and S272 (XREF_FIG), which correlated with mTORC1 activation (XREF_FIG), suggesting that MEKK3 could be a bona fide regulator of p62 phosphorylation and mTORC1 activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates
dephosphorylation
|
MAP3K3 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165229 |
Ser520 |
RLQTICMsGTGMRSV |
Homo sapiens |
|
| pmid |
sentence |
| 20448038 |
Overexpression of pp2a catalytic subunit (pp2ac) beta-isoform results in dephosphorylation of mekk3 at thr-516 and ser-520 and termination of mekk3-mediated nf-kappab activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165233 |
Ser526 |
MSGTGMRsVTGTPYW |
Homo sapiens |
|
| pmid |
sentence |
| 20448038 |
Pp2ac binds to the phosphorylated mekk3 and subsequently dephosphorylate mekk3 at thr-516, ser-520, and ser-526 residues to terminate mekk3-mediated ikkbeta/Nf-kappaB Activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165237 |
Thr516 |
GASKRLQtICMSGTG |
Homo sapiens |
|
| pmid |
sentence |
| 20448038 |
Overexpression of pp2a catalytic subunit (pp2ac) beta-isoform results in dephosphorylation of mekk3 at thr-516 and ser-520 and termination of mekk3-mediated nf-kappab activation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates
phosphorylation
|
MAP3K3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143647 |
Ser526 |
MSGTGMRsVTGTPYW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16407301 |
Phosphorylation of serine 526 is required for mekk3 activity, and association with 14-3-3 blocks dephosphorylationautophosphorylation of mekk3 at ser526 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates quantity by stabilization
binding
|
WDR62 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271714 |
|
|
|
|
| pmid |
sentence |
| 30566428 |
Specifically, we demonstrate that MEKK3 interacts with WDR62 to stabilize WDR62 and regulates JNK activity in a synergic way. On the other hand, JNK activity also regulates the phosphorylation of WDR62 at T1053 in a feedback loop which facilities the recruitment of FBW7 degradation of WDR62 |
|
| Publications: |
1 |
| + |
MAP3K3 | up-regulates activity
binding
|
MAP2K4 |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48628 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 9162092 |
These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates 
|
MAP2K6 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10347227 |
However, the autocatalytic activities of both mkk6 and mkk7 were enhanced by their coexpression with either mekk3 or mekk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF7 | up-regulates
binding
|
MAP3K3 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15001576 |
Traf7 specifically interacts with and activates mekk3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates
phosphorylation
|
MAP2K5 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12912994 |
Mekk2 and mekk3 are mapk kinase kinases that bind, phosphorylate and activate mek5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDR62 | up-regulates activity
relocalization
|
MAP3K3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271717 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 30566428 |
In the WT brain, the WDR62 scaffold organizes a protein complex including MEKK3, MKK4/7, and JNK1 to control NPC development during corticogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
MAP3K3
- 
- 