4.0
Summary
| Name |  PSMD2View Modifications |
| Full Name | 26S proteasome non-ATPase regulatory subunit 2 |
| Synonyms | 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Protein 55.11, Tumor necrosis factor type 1 receptor-associated protein 2 | TRAP2 |
| Primary ID | Q13200 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Inhibitors | bortezomib |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP4K2 | up-regulates activity 
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PIM2 | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PIM3 | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | NEK6 | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PIM1 | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PKA | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAP4K1 | up-regulates activity
phosphorylation
|
PSMD2 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | bortezomib | down-regulates activity 
chemical inhibition
|
PSMD2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PSMD2 | form complex 
binding
|
26S Proteasome | 0.892 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBE3A | down-regulates quantity by destabilization
ubiquitination
|
PSMD2 | 0.277 |
| Publications: | 1 | Organism: | Homo Sapiens | |