| + |
MAP4K1 | up-regulates 
phosphorylation
|
MAP3K11 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83415 |
Ser281 |
WHKTTQMsAAGTYAW |
Homo sapiens |
|
| pmid |
sentence |
| 11053428 |
Hpk1 also phosphorylated mlk-3 activation loop in vitro, and ser281 was found to be the major phosphorylation site, indicating that hpk1 also activates mlk-3 via phosphorylation of the kinase activation loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates activity
phosphorylation
|
PSMD2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273899 |
Ser361 |
ENNRFGGsGSQVDSA |
in vitro |
|
| pmid |
sentence |
| 31843888 |
Seven of these kinases (PIM1/2/3, MAP4K1/2, PKA, and NEK6) directly and robustly phosphorylated recombinant GST-Rpn1 at S361 in vitro (Fig. 3D and SI Appendix, Fig. S3 A and B). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAP4K1 | down-regulates activity 
phosphorylation
|
LCP2 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274153 |
Ser376 |
PRKQLSESSDDDYDD |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 17353368 |
The serine/threonine kinase HPK-1 phosphorylates serine 376 of SLP-76 and induces the interaction with 14-3-3 proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates
phosphorylation
|
LCP2 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153613 |
Ser376 |
SSFPQSAsLPPYFSQ |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17353368 |
The serine/threonine kinase hpk-1 phosphorylates serine 376 of slp-76 and induces the interaction with 14-3-3 proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates activity
phosphorylation
|
CARD11 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276259 |
Ser556 |
TKMQPPRsRSSIMSI |
in vitro |
|
| pmid |
sentence |
| 19706536 |
HPK1 interacts with CARMA1 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARMA1. Interestingly, the putative HPK1 phosphorylation sites in CARMA1 are different from known PKC consensus sites. Mutations of residues S549, S551, and S552 in CARMA1 abrogated phosphorylation of a CARMA1-linker construct by HPK1 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276257 |
Ser558 |
MQPPRSRsSIMSITA |
in vitro |
|
| pmid |
sentence |
| 19706536 |
HPK1 interacts with CARMA1 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARMA1. Interestingly, the putative HPK1 phosphorylation sites in CARMA1 are different from known PKC consensus sites. Mutations of residues S549, S551, and S552 in CARMA1 abrogated phosphorylation of a CARMA1-linker construct by HPK1 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276258 |
Ser559 |
QPPRSRSsIMSITAE |
in vitro |
|
| pmid |
sentence |
| 19706536 |
HPK1 interacts with CARMA1 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARMA1. Interestingly, the putative HPK1 phosphorylation sites in CARMA1 are different from known PKC consensus sites. Mutations of residues S549, S551, and S552 in CARMA1 abrogated phosphorylation of a CARMA1-linker construct by HPK1 in vitro. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
MAP4K1 | up-regulates
phosphorylation
|
MAP4K1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134490 |
Thr165 |
ISAQIGAtLARRLSF |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15743830 |
Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase d1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SAPK/JNK Signaling |
| + |
ABL1 | up-regulates activity
phosphorylation
|
MAP4K1 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251429 |
Tyr232 |
FLMTKSGyQPPRLKE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11278340 |
C-Abl phosphorylates HPK1 in cytoplasm and stimulates HPK1 activity. the c-Abl phosphorylation site (YXXP) in HPK1 (Y232QPP; aa 232–235) is localized in HPK1-KD |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYN | up-regulates activity
phosphorylation
|
MAP4K1 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251403 |
Tyr381 |
SESSDDDyDDVDIPT |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 11514608 |
BCR ligation induced rapid tyrosine-phosphorylation of HPK1 mainly by Syk and Lyn, resulting in its association with BASH and catalytic activation. Tyr-379 within HPK1 is essential for binding to BASH and thus strongly suggest that the DDDYDDV sequence containing the phosphorylated Tyr-379 is the binding site for the BASH SH2 domain. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | EBV infection |
| + |
SYK | up-regulates activity
phosphorylation
|
MAP4K1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246567 |
Tyr381 |
SESSDDDyDDVDIPT |
Homo sapiens |
|
| pmid |
sentence |
| 11514608 |
BCR ligation induced rapid tyrosine-phosphorylation of HPK1 mainly by Syk and Lyn, resulting in its association with BASH and catalytic activation. BCR-mediated activation of HPK1 was impaired in Syk- or BASH-deficient B cells. The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-phosphorylation site were both necessary for interaction of both proteins and efficient HPK1 activation after BCR stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates
phosphorylation
|
MAP3K1 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8824585 |
Hpk1 binds and phosphorylates mekk1 directly, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SAPK/JNK Signaling |
| + |
GRB2 | up-regulates
binding
|
MAP4K1 |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63994 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9891069 |
The first and second proline-rich motifs containing the grb2 n-sh3-binding consensus sequence (-p-x-x-p-x-r/k-) were implicated in the binding of hpk1 to grb2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
CRK | up-regulates
binding
|
MAP4K1 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63988 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9891069 |
We found that hpk1 interacted with crk and crkl adaptor proteins in vitro and in vivo and that the proline-rich motifs within hpk1 were involved in the differential interaction of hpk1 with the crk proteins and grb2. Crk and crkl not only activated hpk1 but also synergized with hpk1 in the activation of jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
MAP4K1 | down-regulates 
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274563 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 17353368 |
Thus, our study reveals the mechanism of a novel negative feedback loop initiated from SLP-76 to modulate signal intensity during T cell activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
MAP4K1 | up-regulates 
|
MAPK8 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8824585 |
These results demonstrated that the observed jnk1 activation was from hpk1 and not from other hpkl-associated kinases or from cross-reactive kinases precipitated by anti-hpk1 antibody. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
CRKL | up-regulates
binding
|
MAP4K1 |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63991 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9891069 |
We found that hpk1 interacted with crk and crkl adaptor proteins in vitro and in vivo and that the proline-rich motifs within hpk1 were involved in the differential interaction of hpk1 with the crk proteins and grb2. Crk and crkl not only activated hpk1 but also synergized with hpk1 in the activation of jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates
|
MAP3K7 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67321 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10224067 |
These studies establish that hpk1 acts as an upstream activator for the tak1-sek-jnk1 module in relaying the tgf-_ signal into the nuclei in 293t cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SAPK/JNK Signaling |
3.0
MAP4K1
- 
- 