Summary

Name MAP4K1
Full Name Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1 | HPK1
Primary ID Q92918
Links - -
Type protein
Relations 15
Pathways EBV infection, SAPK/JNK Signaling
Function Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MAP3K11 0.551
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSMD2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LCP2 0.768
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LCP2 0.768
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP4K1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP4K1 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP4K1 0.39
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EBV infection
+ up-regulates activity img/direct-activation.png phosphorylation MAP4K1 0.354
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP4K1 0.673
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.427
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SAPK/JNK Signaling
+ up-regulates img/direct-activation.png binding MAP4K1 0.467
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/indirect-activation.png MAP3K7 0.531
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SAPK/JNK Signaling
+ down-regulates img/indirect_inhibition.png T_cell_activation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ up-regulates img/indirect-activation.png MAPK8 0.326
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png binding MAP4K1 0.567
Publications: 1 Organism: Homo Sapiens