+ |
MTA1 | form complex
binding
|
MBD2/NuRD complex |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263842 |
|
|
Homo sapiens |
|
pmid |
sentence |
27098840 |
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. This complex is important for early development and for the stability and repair of our genes. Three proteins make up its core: HDAC1, which removes the acetyl group from the nucleosome; MTA1, which acts as a scaffold to hold the complex together; and RBBP4, which enables the complex to interact with nucleosomes. MBD2 and MBD3 are members of the methyl cytosine-guanosine (CpG)-binding domain (MBD) family of proteins42; 43. Of the five MBD members, only MBD2 and MBD3 associate with NuRD and are required for the complex formation and gene repression. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
COP1 | down-regulates quantity by destabilization
polyubiquitination
|
MTA1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271891 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
19805145 |
Here we report that MTA1 is an ubiquitinated protein and targeted by the RING-finger E3 ubiquitin-protein ligase constitutive photomorphogenesis protein 1 (COP1) for degradation via the ubiquitin-proteasome pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | up-regulates quantity by expression
transcriptional regulation
|
CXCL1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254598 |
|
|
Homo sapiens |
OVCAR-3 Cell |
pmid |
sentence |
18719363 |
Screening for the expression of angiogenic cytokines expressed by ovarian cancer cells revealed MTA1-mediated upregulation of the oncogenic and angiogenic cytokine GRO (growth-regulated oncogene, CXCL1). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.436 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254597 |
|
|
Homo sapiens |
OVCAR-3 Cell |
pmid |
sentence |
18719363 |
MTA1 overexpression resulted in downregulation of E-cadherin and MTA3 expression and enhanced expression of the transcriptional repressors SNAIL and SLUG. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | up-regulates activity
binding
|
CLOCK/BMAL1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253723 |
|
|
Mus musculus |
|
pmid |
sentence |
24089055 |
Here we provide genetic and biochemical evidence that metastasis-associated protein 1 (MTA1), a widely upregulated gene product in human cancers, is an integral component of the circadian molecular machinery. | The CLOCK-BMAL1 heterodimer activates MTA1 transcription through a conserved E-box element at its promoter. MTA1, in turn, interacts with and recruits CLOCK-BMAL1 at its own and CRY1 promoters and promotes their transcription. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
MTA1 | down-regulates quantity by repression
transcriptional regulation
|
MTA3 |
0.638 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254595 |
|
|
Homo sapiens |
|
pmid |
sentence |
18719363 |
MTA1 overexpression resulted in downregulation of E-cadherin and MTA3 expression and enhanced expression of the transcriptional repressors SNAIL and SLUG. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PITX3 | up-regulates activity
binding
|
MTA1 |
0.33 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-239770 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
21368136 |
we found that the MTA1/DJ1 complex is required for optimum stimulation of the TH expression by paired like homeodomain transcription factor (Pitx3) homeodomain transcription factor and that the MTA1/DJ1 complex is recruited to the TH gene chromatin via the direct interaction of MTA1 with Pitx3. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | up-regulates quantity by expression
transcriptional regulation
|
SNAI1 |
0.477 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254596 |
|
|
Homo sapiens |
OVCAR-3 Cell |
pmid |
sentence |
18719363 |
MTA1 overexpression resulted in downregulation of E-cadherin and MTA3 expression and enhanced expression of the transcriptional repressors SNAIL and SLUG. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | form complex
binding
|
MBD3/NuRD complex |
0.811 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263854 |
|
|
Homo sapiens |
|
pmid |
sentence |
27098840 |
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. This complex is important for early development and for the stability and repair of our genes. Three proteins make up its core: HDAC1, which removes the acetyl group from the nucleosome; MTA1, which acts as a scaffold to hold the complex together; and RBBP4, which enables the complex to interact with nucleosomes. MBD2 and MBD3 are members of the methyl cytosine-guanosine (CpG)-binding domain (MBD) family of proteins42; 43. Of the five MBD members, only MBD2 and MBD3 associate with NuRD and are required for the complex formation and gene repression. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | down-regulates quantity by repression
transcriptional regulation
|
EPHA2 |
0.292 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254242 |
|
|
Homo sapiens |
Breast Epithelial Cell |
pmid |
sentence |
22184117 |
The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). we observe that inactivation of endogenous HIC1 through RNA interference in normal breast epithelial cells results in the up-regulation of EphA2 and is correlated with increased cellular migration. chromatin immunoprecipitation (ChIP) and sequential ChIP experiments demonstrate that endogenous HIC1 proteins are bound, together with the MTA1 corepressor, to the EphA2 promoter in WI38 cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CLOCK/BMAL1 | up-regulates quantity by expression
transcriptional regulation
|
MTA1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253718 |
|
|
Mus musculus |
|
pmid |
sentence |
24089055 |
Here we provide genetic and biochemical evidence that metastasis-associated protein 1 (MTA1), a widely upregulated gene product in human cancers, is an integral component of the circadian molecular machinery. | The CLOCK-BMAL1 heterodimer activates MTA1 transcription through a conserved E-box element at its promoter. MTA1, in turn, interacts with and recruits CLOCK-BMAL1 at its own and CRY1 promoters and promotes their transcription. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
MTA1 | form complex
binding
|
MTA1/DJ1 complex |
0.333 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-239739 |
|
|
Homo sapiens |
|
pmid |
sentence |
21368136 |
We found that the MTA1/DJ1 complex is required for optimum stimulation of the TH expression by paired like homeodomain transcription factor (Pitx3) homeodomain transcription factor and that the MTA1/DJ1 complex is recruited to the TH gene chromatin via the direct interaction of MTA1 with Pitx3. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | down-regulates quantity by repression
transcriptional regulation
|
CDH1 |
0.425 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254594 |
|
|
Homo sapiens |
OVCAR-3 Cell |
pmid |
sentence |
18719363 |
MTA1 overexpression resulted in downregulation of E-cadherin and MTA3 expression and enhanced expression of the transcriptional repressors SNAIL and SLUG. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTA1 | down-regulates quantity by destabilization
binding
|
COP1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271892 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
19805145 |
MTA1 destabilizes COP1 by promoting its autoubiquitination. in addition to polyubiquitination of its substrates, COP1 also catalyzes its autoubiquitination for degradation as a part of an autoregulatory mechanism |
|
Publications: |
1 |
Organism: |
Homo Sapiens |