| + |
CyclinE/CDK2 | down-regulates quantity by destabilization 
phosphorylation
|
SNAI2 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276629 |
Ser104 |
KDHSGSEsPISDEEE |
Homo sapiens |
|
| pmid |
sentence |
| 24662826 |
At G1/S transition, cyclin E-cyclin-dependent kinase 2 mediates the phosphorylation of Slug at Ser-54 and Ser-104, resulting in its ubiquitylation and degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276628 |
Ser54 |
ILSSGAYsPITVWTT |
Homo sapiens |
|
| pmid |
sentence |
| 24662826 |
At G1/S transition, cyclin E-cyclin-dependent kinase 2 mediates the phosphorylation of Slug at Ser-54 and Ser-104, resulting in its ubiquitylation and degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PAK4 | up-regulates quantity by stabilization 
phosphorylation
|
SNAI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277393 |
Ser158 |
CDAQSRKsFSCKYCD |
in vitro |
|
| pmid |
sentence |
| 29849120 |
PAK4 bound and directly phosphorylated Slug at two previously unknown sites, S158 and S254, which resulted in its stabilization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277394 |
Ser254 |
SKTFSRMsLLHKHEE |
in vitro |
|
| pmid |
sentence |
| 29849120 |
PAK4 bound and directly phosphorylated Slug at two previously unknown sites, S158 and S254, which resulted in its stabilization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280057 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30685413 |
P21 activated kinase 4 (PAK4) directly phosphorylates Slug, resulting in pro malignant Slug stabilization. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens |
| + |
PKA | down-regulates quantity by destabilization
phosphorylation
|
SNAI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277905 |
Ser247 |
KYQCKNCsKTFSRMS |
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 37596321 |
PKA-dependent phosphorylation is pivotal for FBXO28-mediated SNAI2 degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU2F1 | up-regulates quantity by expression 
transcriptional regulation
|
SNAI2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23836662 |
This PER2-OCT1 interaction effectively converted OCT1 sites, which normally activate expression, into repressor sites by recruitment of a polycomb repressor complex including EZH2 and SUZ12, as well as HDAC2. We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
MMP9 |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255170 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22074556 |
We demonstrated that forced expression of SLUG elevated CXCR4 and CXCL12 expression in human prostate cancer cell lines PC3, DU145, 22RV1, and LNCaP; conversely, reduced expression of SLUG by shRNA downregulated CXCR4 and CXCL12 expression at RNA and protein levels in prostate cancer cells. Furthermore, ectopic expression of SLUG increased MMP9 expression and activity in PC3, 22RV1, and DU-145 cells, and SLUG knockdown by shRNA downregulated MMP9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
JAG1 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255151 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20509143 |
SLUG up-regulation engenders breast cancer cells with stem cell-like properties including enhanced expression of CD44 and Jagged-1 in conjunction with estrogen receptor alpha down-regulation, growth as mammospheres, and extracellular matrix invasiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC2 | down-regulates quantity by repression 
transcriptional regulation
|
SNAI2 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254156 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23836662 |
We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Skp1-Pam E3 | down-regulates quantity by destabilization
polyubiquitination
|
SNAI2 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272189 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25460509 |
One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45) through the ubiquitin proteasome system (UPS). The key step is recognition of EMT-TFs by Fbxo45 through its SPRY domain for Zeb2, or F-box domain for the other three EMT-TFs Snai1, Snai2 and Twist1, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
CXCL12 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255169 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22074556 |
We demonstrated that forced expression of SLUG elevated CXCR4 and CXCL12 expression in human prostate cancer cell lines PC3, DU145, 22RV1, and LNCaP; conversely, reduced expression of SLUG by shRNA downregulated CXCR4 and CXCL12 expression at RNA and protein levels in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20509143 |
we show that TNFα treatment of human breast cancer cells up-regulates SLUG with a dependency on canonical NF-κB/HIF1α signaling, which is strongly enhanced by p53 inactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI1 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281172 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 18832382 |
We then analyzed the effect of Snail1 depletion on expression of the other four E-cadherin repressors, whose levels become increased by HMGA2 overexpression, Snail2, ZEB1, ZEB2, and Twist in the same panel of cells (Fig. 7, A–C). Depletion of the induced Snail1 levels by the shRNA led to a concomitant and significant decrease in Snail2, ZEB1, and ZEB2 mRNA levels. In the case of ZEB1 and ZEB2, their expression was decreased almost down to the levels of the parental epithelial cells (NMuMG-m). In contrast, Twist levels remained unaltered by the knock-down of endogenous Snail1 (Fig. 7C). These results demonstrate that Snail1 regulates specifically the expression of Snail2, ZEB1, and ZEB2 but not that of Twist. The data suggest that HMGA2 causes EMT by inducing at least two primary transcriptional mediators of this process, Snail1 and Twist. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281173 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 18832382 |
We then analyzed the effect of Snail1 depletion on expression of the other four E-cadherin repressors, whose levels become increased by HMGA2 overexpression, Snail2, ZEB1, ZEB2, and Twist in the same panel of cells (Fig. 7, A–C). Depletion of the induced Snail1 levels by the shRNA led to a concomitant and significant decrease in Snail2, ZEB1, and ZEB2 mRNA levels. In the case of ZEB1 and ZEB2, their expression was decreased almost down to the levels of the parental epithelial cells (NMuMG-m). In contrast, Twist levels remained unaltered by the knock-down of endogenous Snail1 (Fig. 7C). These results demonstrate that Snail1 regulates specifically the expression of Snail2, ZEB1, and ZEB2 but not that of Twist. The data suggest that HMGA2 causes EMT by inducing at least two primary transcriptional mediators of this process, Snail1 and Twist. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255176 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 21044962 |
knockdown of SLUG in SLUG-high breast cancer cells elevated the levels of UbcH5c while decreasing the level of cyclin D1 protein. SLUG is recruited at the E2-box sequence at the UbcH5c gene promoter along with the corepressor CtBP1 and the effector HDAC1 to silence the expression of this gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | down-regulates quantity by repression
transcriptional regulation
|
UBE2D3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255173 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 21044962 |
knockdown of SLUG in SLUG-high breast cancer cells elevated the levels of UbcH5c while decreasing the level of cyclin D1 protein. SLUG is recruited at the E2-box sequence at the UbcH5c gene promoter along with the corepressor CtBP1 and the effector HDAC1 to silence the expression of this gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTA1 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254597 |
|
|
Homo sapiens |
OVCAR-3 Cell |
| pmid |
sentence |
| 18719363 |
MTA1 overexpression resulted in downregulation of E-cadherin and MTA3 expression and enhanced expression of the transcriptional repressors SNAIL and SLUG. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | down-regulates quantity by repression
transcriptional regulation
|
VDR |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255177 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 18485278 |
We have shown here that the transcriptional repressor protein SLUG inhibits the expression of VDR in human breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | down-regulates quantity by repression
transcriptional regulation
|
CDH1 |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15311212 |
Known E-cadherin transcriptional repressors, such as SLUG (SNAI2), SIP1 (ZEB2), TWIST1, SNAIL (SNAI1) and ZEB1 (TCF8), but not E12/E47 (TCF3), had a lack of upregulation in cells expressing mutated E-cadherin compared to WT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PER2 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254147 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 23836662 |
PER2 Suppresses TWIST1 and SLUG Transcription by Recruiting EZH2, SUZ12, and HDAC2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
CD44 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255153 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20509143 |
SLUG up-regulation engenders breast cancer cells with stem cell-like properties including enhanced expression of CD44 and Jagged-1 in conjunction with estrogen receptor alpha down-regulation, growth as mammospheres, and extracellular matrix invasiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | down-regulates quantity by repression
transcriptional regulation
|
ESR1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255154 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20509143 |
SLUG up-regulation engenders breast cancer cells with stem cell-like properties including enhanced expression of CD44 and Jagged-1 in conjunction with estrogen receptor alpha down-regulation, growth as mammospheres, and extracellular matrix invasiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | down-regulates quantity by repression
transcriptional regulation
|
HPGD |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255172 |
|
|
Homo sapiens |
Non-small Cell Lung Adenocarcinoma Cell Line |
| pmid |
sentence |
| 17575121 |
the Slug protein, but not ZEB1, binds to the PGDH promoter and represses transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SUZ12 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23836662 |
We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESR1 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18588516 |
The down-regulation of slug in the ERalpha-positive MCF-7 cell line was mediated by direct repression of slug transcription by the formation of a co-repressor complex involving ligand-activated ERalpha protein, HDAC1 (histone deacetylase 1) and N-CoR (nuclear receptor co-repressor). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23836662 |
We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity
phosphorylation
|
SNAI2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23851495 |
GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP mediated degradation of Slug.|Phosphorylation of Slug by GSK3beta promotes CHIP binding and ubiquitin mediated proteolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOR1 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18588516 |
The down-regulation of slug in the ERalpha-positive MCF-7 cell line was mediated by direct repression of slug transcription by the formation of a co-repressor complex involving ligand-activated ERalpha protein, HDAC1 (histone deacetylase 1) and N-CoR (nuclear receptor co-repressor). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
CXCR4 |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255171 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22074556 |
We demonstrated that forced expression of SLUG elevated CXCR4 and CXCL12 expression in human prostate cancer cell lines PC3, DU145, 22RV1, and LNCaP; conversely, reduced expression of SLUG by shRNA downregulated CXCR4 and CXCL12 expression at RNA and protein levels in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
VIM |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34638469 |
These signalling cascades are also implicated in the induction of EMT via the transcriptional control of EMT-associated transcription factors, such as SNAI1, TWIST, ZEB1, SLUG and TCF3 leading to vimentin expression, as described above (Figure 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262038 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B/Axin/APC | down-regulates quantity by destabilization
phosphorylation
|
SNAI2 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281174 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22727060 |
In this study, we have demonstrated the inhibitory effects of Slug/Snail2 phosphorylation by GSK-3β on EMT. GSK-3β can regulate Snail1 function via phosphorylation at two consensus motifs: phosphorylation at the first motif regulates its ubiquitination by β-transducin repeat containing protein (β-TrCP), whereas phosphorylation at the second motif controls its subcellular localization [10]. A non-phosphorylated variant of Snail1 resides more stably in the nucleus to exclusively induce EMT [5]. GSK-3β can inhibit Snail1 expression via inhibiting its transcription [11], as well as by regulating Snail1 degradation and nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST1 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20646316 |
Individual genes upregulated by TWIST1 known to promote EMT and/or GBM invasion included SNAI2, MMP2, HGF, FAP and FN1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18588516 |
The down-regulation of slug in the ERalpha-positive MCF-7 cell line was mediated by direct repression of slug transcription by the formation of a co-repressor complex involving ligand-activated ERalpha protein, HDAC1 (histone deacetylase 1) and N-CoR (nuclear receptor co-repressor). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255080 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22641097 |
Effective silencing of Runx2 by short interfering RNA (siRNA) demonstrated downregulation of EMT-related molecules (SNAI2, SNAI3 and TWIST1), MMP2 and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESRRA | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO45 | down-regulates quantity by destabilization
binding
|
SNAI2 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272182 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25460509 |
One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45) through the ubiquitin proteasome system (UPS). The key step is recognition of EMT-TFs by Fbxo45 through its SPRY domain for Zeb2, or F-box domain for the other three EMT-TFs Snai1, Snai2 and Twist1, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
SNAI2 |
0.51 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23973264 |
Notch directly stimulates the Slug promoter, resulting in the up-regulation of Slug and initiation of EMT in endothelial cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SNAI2
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