| + |
LNPEP | down-regulates quantity by destabilization 
cleavage
|
Oxytocin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25767437 |
It has been shown that the steady state of the mature OT form can be controlled by an oxytocinase (P-LAP) that is produced in periphery and centrally by the OT-magnocellular neurons. Noticeably, P-LAP is also expressed in parvocellular OT neurons and in other brain structures| The OT intermediate forms are produced from E16.5 (see above) but the mature amidated OT form is detected only from birth. The released mature form is then degraded by an oxytocinase (PLAP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
IKZF1 | up-regulates quantity by expression 
transcriptional regulation
|
LNPEP |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255403 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFAP2A | up-regulates quantity by expression
transcriptional regulation
|
LNPEP |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255402 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKZF2 | up-regulates quantity by expression
transcriptional regulation
|
LNPEP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255404 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKZF5 | up-regulates quantity by expression
transcriptional regulation
|
LNPEP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255407 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKZF4 | up-regulates quantity by expression
transcriptional regulation
|
LNPEP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255406 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKZF3 | up-regulates quantity by expression
transcriptional regulation
|
LNPEP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255405 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LNPEP
- 
- 