Summary

Name ATR
Full Name Serine/threonine-protein kinase ATR
Synonyms Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1 | FRP1
Primary ID Q13535
Links - -
Type protein
Relations 57
Pathways DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
Function Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CREB1 0.354
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ img/unknown.png phosphorylation MCM2 0.696
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BRCA1 0.791
Publications: 6 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation MCC 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FANCA 0.576
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png phosphorylation XPA 0.508
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation XPA 0.508
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATM 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png phosphorylation XRCC3 0.482
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation E2F1 0.385
Publications: 1 Organism: Mus Musculus
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation CHEK1 0.923
Publications: 2 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G2/M phase transition
+ img/unknown.png phosphorylation RPA2 0.746
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NBN 0.776
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.5
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png phosphorylation DBF4 0.643
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KMT2A 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation POLH 0.427
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ up-regulates activity img/direct-activation.png phosphorylation RAD17 0.853
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMARCAL1 0.516
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATRIP 0.872
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FANCD2 0.658
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZDHHC13 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PRKDC 0.319
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation CCAR2 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CHEK2 0.856
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png phosphorylation WDHD1 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RBBP8 0.6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATR 0.578
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png binding ATR
Publications: 1
+ up-regulates img/direct-activation.png binding ATR 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ATR 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates img/direct-activation.png binding XPC 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATR 0.638
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation USP20 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PI4K2A 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.791
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation MCM6 0.542
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATR 0.807
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATR 0.402
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation MCM4 0.714
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CDS1 0.358
Publications: 1 Organism: Homo Sapiens