Summary

Name TP53BP2
Full Name Apoptosis-stimulating of p53 protein 2
Synonyms Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2 | ASPP2, BBP
Primary ID Q13625
Links - -
Type protein
Relations 3
Function Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation TP53BP2 0.268
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding TP53 0.895
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPP1R14A 0.2
Publications: 1 Organism: Homo Sapiens