4.0
Summary
| Name |  TP53BP2View Modifications |
| Full Name | Apoptosis-stimulating of p53 protein 2 |
| Synonyms | Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2 | ASPP2, BBP |
| Primary ID | Q13625 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK1 | up-regulates activity 
phosphorylation
|
TP53BP2 | 0.264 |
| Publications: | 1 | Organism: | In Vitro | |
| + | TP53BP2 | down-regulates 
binding
|
PPP1R14A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TP53BP2 | up-regulates
binding
|
TP53 | 0.899 |
| Publications: | 1 | Organism: | Homo Sapiens | |