3.0
Summary
| Name |  RAPGEF1View Modifications |
| Full Name | Rap guanine nucleotide exchange factor 1 |
| Synonyms | CRK SH3-binding GNRP, Guanine nucleotide-releasing factor 2, Protein C3G | GRF2 |
| Primary ID | Q13905 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | HCK | up-regulates 
phosphorylation
|
RAPGEF1 | 0.516 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | up-regulates
phosphorylation
|
RAPGEF1 | 0.659 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABL1 |
phosphorylation
|
RAPGEF1 | 0.556 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CRK | up-regulates
binding
|
RAPGEF1 | 0.898 |
| Publications: | 1 | Organism: | Homo Sapiens | |