| + |
CDK2 | up-regulates activity 
phosphorylation
|
RNF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276901 |
Thr112 |
DVYVTTHtPRNARDE |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25948581 |
Here we reported that CDK2 could phosphorylate RNF4 on T26 and T112 and enhance RNF4 E3 ligase activity, which is important for MDC1 degradation and proper HR repair during S phase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276900 |
Thr26 |
RTREATStPEISLEA |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25948581 |
Here we reported that CDK2 could phosphorylate RNF4 on T26 and T112 and enhance RNF4 E3 ligase activity, which is important for MDC1 degradation and proper HR repair during S phase. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RNF4 | down-regulates quantity by destabilization 
polyubiquitination
|
SP1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272720 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21983342 |
Here, we identified RNF4 as the ubiquitin E3 ligase of Sp1. From in vitro and in vivo experiments, we found that sumoylated Sp1 can recruit RNF4 as a ubiquitin E3 ligase that subjects sumoylated Sp1 to proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | down-regulates quantity by destabilization
sumoylation
|
KDM5B |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33859667 |
Hendriks and coworkers showed that, in response to alkylation damage by methyl methanesulfonate (MMS), SUMOylated JARID1B (KDM5B) is ubiquitylated by the SUMOtargeted ubiquitin ligase RNF4 and degraded by the proteasome, whereas JARID1C (KDM5C) is SUMOylated and recruited to the chromatin to demethylate histone H3K4 (Hendriks et al., 2015). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PATZ1 | down-regulates
binding
|
RNF4 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10713105 |
In vitro and in vivo interaction between rnf4 and patz was demonstrated / patz acted as a transcriptional repressor, whereas its partner rnf4 behaved as a transcriptional activator./ the association of patz with rnf4 switches activation to repression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
RNF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | up-regulates activity
binding
|
NFYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252231 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15496512 |
Coactivator RNF4 is involved in the GCH gene expression. Through serial deletion and mutagenesis studies of the GCH promoter, we defined the RNF4-responsive element on GCH proximal promoter as a CCAAT box. RNF4 did not possess specific DNA binding activity toward this CCAAT box, which suggests that RNF4 may be a coactivator of the CCAAT boxbinding protein nuclear factor Y (NF-Y). RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | up-regulates activity
sumoylation
|
KDM5C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271576 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33859667 |
Hendriks and coworkers showed that, in response to alkylation damage by methyl methanesulfonate (MMS), SUMOylated JARID1B (KDM5B) is ubiquitylated by the SUMOtargeted ubiquitin ligase RNF4 and degraded by the proteasome, whereas JARID1C (KDM5C) is SUMOylated and recruited to the chromatin to demethylate histone H3K4 (Hendriks et al., 2015). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | down-regulates quantity by destabilization
polyubiquitination
|
SUMO2 |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272640 |
|
|
in vitro |
|
| pmid |
sentence |
| 18408734 |
Here we demonstrate that the RING-domain-containing ubiquitin E3 ligase, RNF4 (also known as SNURF), targets poly-SUMO-modified proteins for degradation mediated by ubiquitin. RNF4 depletion or proteasome inhibition led to accumulation of mixed, polyubiquitinated, poly-SUMO chains. PML protein accumulated in RNF4-depleted cells and was ubiquitinated by RNF4 in a SUMO-dependent fashion in vitro.RNF4 preferentially binds to and ubiquitinates SUMO-2 polymers over SUMO-2 monomers in vitro |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RNF4 | down-regulates quantity by destabilization
polyubiquitination
|
PML |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272884 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23530056 |
Upon TGF-β induction, interaction of Arkadia with phosphorylated Smad2 triggers degradation of SnoN, whereas upon arsenic treatment, interaction of Arkadia with poly-SUMO in PML nuclear bodies induces degradation of polysumoylated PML together with RNF4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | up-regulates activity
binding
|
NFYA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15496512 |
Coactivator RNF4 is involved in the GCH gene expression. Through serial deletion and mutagenesis studies of the GCH promoter, we defined the RNF4-responsive element on GCH proximal promoter as a CCAAT box. RNF4 did not possess specific DNA binding activity toward this CCAAT box, which suggests that RNF4 may be a coactivator of the CCAAT boxbinding protein nuclear factor Y (NF-Y). RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | up-regulates activity
binding
|
NFYB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15496512 |
Coactivator RNF4 is involved in the GCH gene expression. Through serial deletion and mutagenesis studies of the GCH promoter, we defined the RNF4-responsive element on GCH proximal promoter as a CCAAT box. RNF4 did not possess specific DNA binding activity toward this CCAAT box, which suggests that RNF4 may be a coactivator of the CCAAT boxbinding protein nuclear factor Y (NF-Y). RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RNF4
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