Summary

Name RNF4
Full Name E3 ubiquitin-protein ligase RNF4
Synonyms RING finger protein 4, Small nuclear ring finger protein, Protein SNURF | SNURF
Primary ID P78317
Links - -
Type protein
Relations 4
Function E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding NFYB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NFYA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NFYC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RNF4 0.31
Publications: 1 Organism: Homo Sapiens