| + |
hydrogen peroxide | up-regulates activity 
chemical modification
|
KEAP1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279845 |
CYS226 |
EFFNLSHcQLVTLIS |
Homo sapiens |
|
| pmid |
sentence |
| 32284348 |
In response to oxidative stress, the direct binding of stressors to reactive cysteine residues results in a conformation change in KEAP1, which inhibits the ubiquitination of NRF2. the sensor for H2O2 consists of four residues within KEAP1: Cys226, Cys613, Cys622, and Cys624.KEAP1 uses multiple sensing mechanisms to coordinate the NRF2-dependent oxidative stress response. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279846 |
CYS613 |
VAVTMEPcRKQIDQQ |
Homo sapiens |
|
| pmid |
sentence |
| 32284348 |
In response to oxidative stress, the direct binding of stressors to reactive cysteine residues results in a conformation change in KEAP1, which inhibits the ubiquitination of NRF2. the sensor for H2O2 consists of four residues within KEAP1: Cys226, Cys613, Cys622, and Cys624.KEAP1 uses multiple sensing mechanisms to coordinate the NRF2-dependent oxidative stress response. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279847 |
CYS622 |
KQIDQQNcTC |
Homo sapiens |
|
| pmid |
sentence |
| 32284348 |
In response to oxidative stress, the direct binding of stressors to reactive cysteine residues results in a conformation change in KEAP1, which inhibits the ubiquitination of NRF2. the sensor for H2O2 consists of four residues within KEAP1: Cys226, Cys613, Cys622, and Cys624.KEAP1 uses multiple sensing mechanisms to coordinate the NRF2-dependent oxidative stress response. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279848 |
CYS624 |
IDQQNCTc |
Homo sapiens |
|
| pmid |
sentence |
| 32284348 |
In response to oxidative stress, the direct binding of stressors to reactive cysteine residues results in a conformation change in KEAP1, which inhibits the ubiquitination of NRF2. the sensor for H2O2 consists of four residues within KEAP1: Cys226, Cys613, Cys622, and Cys624.KEAP1 uses multiple sensing mechanisms to coordinate the NRF2-dependent oxidative stress response. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
KEAP1 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 |
0.723 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272646 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 17046835 |
Keap1-dependent ubiquitination of PGAM5 results in proteasome-dependent degradation of PGAM5. Keap1 is a Bric-a-Brac (BTB) 2 -Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
KEAP1 | down-regulates quantity 
ubiquitination
|
NFE2L2 |
0.813 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257023 |
Keap1 is a substrate receptor of a Cul3-RING ubiquitin ligase (CRL3) that, in physiological conditions, constitutively binds and targets Nrf2 for degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
KEAP1 | down-regulates
binding
|
NFE2L2 |
0.813 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24997453 |
Keap1 is an oxidative stress-sensing protein and is a negative regulator of nuclear factor-erythroid-2-related factor 2 (nrf2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
BAP1 | up-regulates quantity by stabilization
binding
|
KEAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268924 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35052618 |
BAP1 directly binds to and deubiquitinates KEAP1. BAP1 stabilizes KEAP1 by binding to the BTB domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SQSTM1 | down-regulates quantity by destabilization
ubiquitination
|
KEAP1 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
When autophagy is impaired, accumulated SQSTM1 interacts with KEAP1, leading to the proteasomal degradation of KEAP1. This interaction sequesters KEAP1 away from NFE2L2, preventing the ubiquitination and degradation of NFE2L2. Consequently, NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KEAP1 | form complex 
binding
|
CUL3-RBX1-KEAP1 |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24138990 |
KEAP1/CUL3/RBX1 E3-ligase protein complex exert different functions under physiological and oxidative conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KEAP1 | down-regulates quantity by destabilization
binding
|
PGAM5 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272645 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 17046835 |
Keap1-dependent ubiquitination of PGAM5 results in proteasome-dependent degradation of PGAM5. Keap1 is a Bric-a-Brac (BTB) 2 -Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DPP3 | down-regulates quantity by destabilization
cleavage
|
KEAP1 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268464 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35278345 |
The influence of DPP3 on the Keap1-Nrf2/ARE signal pathway suggest a direct involvement of DPP3 in the oxidative stress response [8,14,31,53,99,100]. It was shown that DPP3 competes with Nrf2 through the ETGE motif to bind to Keap1 and consequently enhances the translocation of Nrf2 to the nucleus, thereby driving the expression of an array of genes encoding antioxidative enzymes [99]. More specifically, binding of DPP3 to Keap1 releases Nrf2, and thus, prevents its degradation through the 26S proteasome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KEAP1 | up-regulates activity
binding
|
CUL3 |
0.949 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268925 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 15983046 |
Keap1 is a BTB-Kelch protein that functions as a substrate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex. Keap1 targets its substrate, the Nrf2 transcription factor, for ubiquitination and subsequent degradation by the 26 S proteasome. The N-terminal BTB domain and central linker region of Keap1 bind Cul3, whereas the C-terminal Kelch domain of Keap1 binds Nrf2 via residues located within loops that extend out from the bottom of the Kelch domain |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
4.0
KEAP1
- 
- 