+ |
KEAP1 | form complex
binding
|
CUL3-RBX1-KEAP1 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279841 |
|
|
Homo sapiens |
|
pmid |
sentence |
24138990 |
KEAP1/CUL3/RBX1 E3-ligase protein complex exert different functions under physiological and oxidative conditions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CUL3 | form complex
binding
|
CUL3-RBX1-KEAP1 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279842 |
|
|
Homo sapiens |
|
pmid |
sentence |
24138990 |
KEAP1/CUL3/RBX1 E3-ligase protein complex exert different functions under physiological and oxidative conditions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RBX1 | form complex
binding
|
CUL3-RBX1-KEAP1 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279843 |
|
|
Homo sapiens |
|
pmid |
sentence |
24138990 |
KEAP1/CUL3/RBX1 E3-ligase protein complex exert different functions under physiological and oxidative conditions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CUL3-RBX1-KEAP1 | down-regulates quantity by destabilization
ubiquitination
|
NFE2L2 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279844 |
|
|
Homo sapiens |
Pancreatic Ductal Adenocarcinoma Cell |
pmid |
sentence |
39534872 |
NFE2L2 is primarily regulated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, which, under normal conditions, promotes the ubiquitination and proteasomal degradation of NFE2L2, keeping its cellular levels low. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |