Summary

Name ESPL1
Full Name Separin
Synonyms Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase | ESP1, KIAA0165
Primary ID Q14674
Links - -
Type protein
Relations 4
Function Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ESPL1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ESPL1 0.596
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ESPL1 0.943
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage RAD21 0.773
Publications: 1 Organism: Homo Sapiens