+ |
MAPK1 | down-regulates
phosphorylation
|
ESPL1 |
0.28 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-113130 |
Ser1126 |
IAPSTNSsPVLKTKP |
Homo sapiens |
|
pmid |
sentence |
11747808 |
Both cdc2/cyclinb1 and mapk (erk2) efficiently phosphorylate separase at its major inhibitory site in vitro |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK1 | down-regulates
phosphorylation
|
ESPL1 |
0.596 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-113126 |
Ser1126 |
IAPSTNSsPVLKTKP |
Homo sapiens |
|
pmid |
sentence |
11747808 |
Both cdc2/cyclinb1 and mapk (erk2) efficiently phosphorylate separase at its major inhibitory site in vitro |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PTTG1 | down-regulates activity
binding
|
ESPL1 |
0.943 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275538 |
|
|
Homo sapiens |
|
pmid |
sentence |
15737063 |
Prior to anaphase, separase is kept inactive by its inhibitor securin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ESPL1 | down-regulates quantity by destabilization
cleavage
|
RAD21 |
0.773 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275537 |
|
|
Homo sapiens |
|
pmid |
sentence |
15737063 |
In order to segregate sister chromatids to opposite poles in anaphase, cohesin has to be removed from chromosomes. In budding yeast, the prevalent mode of cohesin removal is by proteolytic cleavage of the Scc1 subunit at the onset of anaphase by the endopeptidase separase |
|
Publications: |
1 |
Organism: |
Homo Sapiens |