| + |
CTDNEP1 | up-regulates activity 
dephosphorylation
|
LPIN1 |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248346 |
Ser106 |
IPMHLATsPILSEGA |
Homo sapiens |
BHK Cell |
| pmid |
sentence |
| 17420445 |
Dullard significantly dephosphorylates mouse lipin 1b only in BHK cells (Fig. 5A). This is most clearly seen by using the antibody prepared against the phosphorylation site Ser-106.|Dephosphorylation of lipin results in its translocation to the nuclear envelope and endoplasmic reticulum membranes from the cytosol and generation of diacylglycerol |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
LPIN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277292 |
Tyr398 |
HLGADGVyLDDLTDM |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 33203880 |
Obesity-associated microenvironmental factors and other Src-activating growth factors, including the epidermal growth factor, activate Src and promote Src-mediated lipin-1 phosphorylation on Tyr398, Tyr413 and Tyr795 residues. The tyrosine phosphorylation of lipin-1 markedly increases its PAP activity, accelerating the synthesis of glycerophospholipids and triglyceride. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277293 |
Tyr413 |
DPEVAALyFPKNGDP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 33203880 |
Obesity-associated microenvironmental factors and other Src-activating growth factors, including the epidermal growth factor, activate Src and promote Src-mediated lipin-1 phosphorylation on Tyr398, Tyr413 and Tyr795 residues. The tyrosine phosphorylation of lipin-1 markedly increases its PAP activity, accelerating the synthesis of glycerophospholipids and triglyceride. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277291 |
Tyr795 |
FPNTEPFyAAFGNRP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 33203880 |
Obesity-associated microenvironmental factors and other Src-activating growth factors, including the epidermal growth factor, activate Src and promote Src-mediated lipin-1 phosphorylation on Tyr398, Tyr413 and Tyr795 residues. The tyrosine phosphorylation of lipin-1 markedly increases its PAP activity, accelerating the synthesis of glycerophospholipids and triglyceride. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
3.0
LPIN1
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- 