+ |
ATM | up-regulates quantity by stabilization
phosphorylation
|
USP10 |
0.252 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276276 |
Ser337 |
ASGTLPVsQPKSWAS |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
20096447 |
The translocation and stabilization of USP10 is regulated by ATM -mediated phosphorylation of USP10 at Thr42 and Ser337. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276275 |
Thr42 |
SGTVLCGtQAVDKLP |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
20096447 |
The translocation and stabilization of USP10 is regulated by ATM -mediated phosphorylation of USP10 at Thr42 and Ser337. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
ATM | up-regulates activity
phosphorylation
|
USP10 |
0.252 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279796 |
Ser337 |
ASGTLPVsQPKSWAS |
Homo sapiens |
|
pmid |
sentence |
35627217 |
As shown, both AKT and ATM increase the activity of USP10.|Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1\u2013100) binds to p53 and inhibits its ubiquitination [27]. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279795 |
Thr42 |
SGTVLCGtQAVDKLP |
Homo sapiens |
|
pmid |
sentence |
35627217 |
As shown, both AKT and ATM increase the activity of USP10.|Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1\u2013100) binds to p53 and inhibits its ubiquitination [27]. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PRKAA1 | up-regulates activity
phosphorylation
|
USP10 |
0.31 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277207 |
Ser76 |
DTLPRTPsYSISSTL |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
26876938 |
Under energy stress, USP10 activity in turn is enhanced through AMPK-mediated phosphorylation of Ser76 of USP10. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP10 | up-regulates quantity by stabilization
deubiquitination
|
BECN1 |
0.507 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260299 |
|
|
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
21962518 |
Similarly, the overexpression of USP13 reduced the levels of ubiquitinated Beclin1 which was inhibited by spautin-1 (Figure 4E) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
BECN1 | up-regulates quantity by stabilization
deubiquitination
|
USP10 |
0.507 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260298 |
|
|
Homo sapiens |
H4 Neuroglioma Cell |
pmid |
sentence |
21962518 |
Interestingly, Beclin1 also controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP10 | up-regulates quantity by stabilization
deubiquitination
|
TP53 |
0.66 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260297 |
|
|
Homo sapiens |
H4 Neuroglioma Cell |
pmid |
sentence |
21962518 |
Since USP10 is known as a deubiquitinating protease of p53 (Yuan et al., 2010), inhibition of USP10 by spautin-1 may promote the degradation of p53. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |