Relation Results

Summary

Name GRIN2C
Full Name Glutamate receptor ionotropic, NMDA 2C
Synonyms GluN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C | NMDAR2C
Primary ID Q14957
Links - -
Type protein
Relations 4
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent ...
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Type: Score: Layout: SPV 
0.20.6070.3190.607AKTGRIN2CGRIN1YWHAENMDA receptor_2C

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKTup-regulates activity img/direct-activation.png phosphorylation GRIN2C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262620 Ser1081 GSRPRHAsLPSSVAE Mus musculus Cerebellar Granule Cell
pmid sentence
Here, we demonstrate that PKB/Akt directly phosphorylates NR2C on serine 1096 (S1096). In addition, we identify 14-3-3epsilon as an NR2C interactor, whose binding is dependent on S1096 phosphorylation. These data are all consistent with a model in which NR1 and NR2C oligomerize, PKB phosphorylates S1096, and 14-3-3ε binds to phosphorylated NR2C thereby promoting NR2C-containing NMDA receptor surface expression in cerebellar granule cells.
Publications: 1 Organism: Mus Musculus
+ GRIN2Cup-regulates activity img/direct-activation.png binding GRIN1 0.607
Identifier Residue Sequence Organism Cell Line
SIGNOR-262621 Mus musculus Cerebellar Granule Cell
pmid sentence
Here, we demonstrate that PKB/Akt directly phosphorylates NR2C on serine 1096 (S1096). In addition, we identify 14-3-3epsilon as an NR2C interactor, whose binding is dependent on S1096 phosphorylation. These data are all consistent with a model in which NR1 and NR2C oligomerize, PKB phosphorylates S1096, and 14-3-3ε binds to phosphorylated NR2C thereby promoting NR2C-containing NMDA receptor surface expression in cerebellar granule cells.
Publications: 1 Organism: Mus Musculus
+ YWHAEup-regulates quantity by stabilization img/direct-activation.png binding GRIN2C 0.319
Identifier Residue Sequence Organism Cell Line
SIGNOR-262622 Mus musculus
pmid sentence
Here, we demonstrate that PKB/Akt directly phosphorylates NR2C on serine 1096 (S1096). In addition, we identify 14-3-3epsilon as an NR2C interactor, whose binding is dependent on S1096 phosphorylation. These data are all consistent with a model in which NR1 and NR2C oligomerize, PKB phosphorylates S1096, and 14-3-3ε binds to phosphorylated NR2C thereby promoting NR2C-containing NMDA receptor surface expression in cerebellar granule cells.
Publications: 1 Organism: Mus Musculus
+ GRIN2Cform complex img/form-complex.png binding NMDA receptor_2C 0.607
Identifier Residue Sequence Organism Cell Line
SIGNOR-264125 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
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