Relation Results

Summary

Name NMDA receptor_2C
Primary ID SIGNOR-C349
Links CPX-286
Type complex
Formed by GRIN2C, GRIN1
Relations 10

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Type: Score: Layout: SPV 
0.5840.670.5950.80.80.2920.5950.80.7380.7NMDA receptor_2CCAMK2ADLG3GRIN1glutamic acidD-serineCTTNGRIN2Ccalcium(2+)DLG4Excitatory_synaptic_transmission

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Relations
Regulator
Mechanism
target
score ℹ
+ NMDA receptor_2Cup-regulates activity img/direct-activation.png binding CAMK2A 0.584
Identifier Residue Sequence Organism Cell Line
SIGNOR-264216 Homo sapiens Neuron
pmid sentence
The most abundant signaling protein in the PSD fraction is Ca2+/calmodulin–dependent protein kinase II (CaMKII), which makes up 1 to 2% of the total protein in the forebrain (21). CaMKII is a target for Ca2+ flowing through the NMDA receptor and is necessary for normal synaptic plasticity in pyramidal neurons. The cytosolic tails of the NR2 subunits of the NMDA receptor bind to CaMKII and thus can serve as docking sites for it in the PSD
Publications: 1 Organism: Homo Sapiens
+ DLG3up-regulates activity img/direct-activation.png relocalization NMDA receptor_2C 0.67
Identifier Residue Sequence Organism Cell Line
SIGNOR-266008
pmid sentence
DLG3 plays a critical role in clustering of NMDA receptors at excitatory synapses.
Publications: 1
Tissue: Central Nervous System
+ GRIN1form complex img/form-complex.png binding NMDA receptor_2C 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-264124 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation NMDA receptor_2C 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264130 Homo sapiens
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. Each receptor has two binding sites for glycine and two binding sites for glutamate
Publications: 1 Organism: Homo Sapiens
+ D-serineup-regulates activity img/direct-activation.png chemical activation NMDA receptor_2C 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268279 Homo sapiens Astroglial Cell
pmid sentence
D-serine acts in concert with L-glutamate (triangles) to activate NMDA receptors|D-serine released from astrocytes seems to be an endogenous ligand of the N-methyl-D-aspartate (NMDA) receptor (3, 8). Depletion of endogenous D-serine in slices and cultured cells strongly diminishes NMDA receptor responses measured biochemically and electrophysiologically
Publications: 1 Organism: Homo Sapiens
+ NMDA receptor_2Cup-regulates quantity img/direct-activation.png relocalization CTTN 0.292
Identifier Residue Sequence Organism Cell Line
SIGNOR-266601 Homo sapiens Brain
pmid sentence
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors.
Publications: 1 Organism: Homo Sapiens
+ GRIN2Cform complex img/form-complex.png binding NMDA receptor_2C 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-264125 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
+ NMDA receptor_2Cup-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264220 Homo sapiens
pmid sentence
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-permeable component of excitatory neurotransmission in the central nervous system (CNS). 
Publications: 1 Organism: Homo Sapiens
+ NMDA receptor_2Cup-regulates activity img/direct-activation.png binding DLG4 0.738
Identifier Residue Sequence Organism Cell Line
SIGNOR-264224 Homo sapiens Neuron
pmid sentence
Another central component of the NMDA receptor signaling complex is the scaffold protein PSD-95 (also referred to as SAP-90). The first and second PDZ domains bind tightly to the tails of the NR2 subunits of the NMDA receptor
Publications: 1 Organism: Homo Sapiens
+ NMDA receptor_2Cup-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264134 Homo sapiens Neuron
pmid sentence
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic.
Publications: 1 Organism: Homo Sapiens
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