| + |
PRKCG | up-regulates activity 
phosphorylation
|
GRIN1 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263176 |
Ser890 |
ITSTLASsFKRRRSS |
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 15936117 |
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. The results show that PKC alpha phosphorylates preferentially S896 and PKC gamma preferentially S890. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PRKCA | up-regulates activity
phosphorylation
|
GRIN1 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263177 |
Ser896 |
SSFKRRRsSKDTSTG |
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 15936117 |
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. The results show that PKC alpha phosphorylates preferentially S896 and PKC gamma preferentially S890. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
GRIN1 | form complex 
binding
|
NMDA receptor_2C |
0.627 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264124 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIN1 | form complex
binding
|
NMDA receptor_2B |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264122 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LNX1 | down-regulates quantity by destabilization 
ubiquitination
|
GRIN1 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272901 |
|
|
in vitro |
|
| pmid |
sentence |
| 22889411 |
We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous substrates, PDZ-binding kinase (PBK) and breakpoint cluster region protein (BCR), were confirmed in vivo. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GRIN1 | form complex
binding
|
NMDA receptor_2A |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264120 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIN1 | form complex
binding
|
NMDA receptor_2D |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264126 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIN2C | up-regulates activity
binding
|
GRIN1 |
0.627 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262621 |
|
|
Mus musculus |
Cerebellar Granule Cell |
| pmid |
sentence |
| 19477150 |
Here, we demonstrate that PKB/Akt directly phosphorylates NR2C on serine 1096 (S1096). In addition, we identify 14-3-3epsilon as an NR2C interactor, whose binding is dependent on S1096 phosphorylation. These data are all consistent with a model in which NR1 and NR2C oligomerize, PKB phosphorylates S1096, and 14-3-3ε binds to phosphorylated NR2C thereby promoting NR2C-containing NMDA receptor surface expression in cerebellar granule cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
GRIN1
- 
- 