| + |
NR1I3 | up-regulates quantity by expression 
transcriptional regulation
|
UGT1A1 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254438 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18172616 |
This study indicates that hepatocyte nuclear factor 1alpha (HNF1alpha) bound to the proximal promoter motif not only enhances the basal reporter activity of UGT1A1, including the distal (-3570/-3180) and proximal (-165/-1) regions, but also influences the transcriptional regulation of UGT1A1 by CAR, PXR, GR, and AhR to markedly enhance reporter activities. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1I3 | up-regulates quantity by expression
transcriptional regulation
|
CYP2B6 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254863 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19702527 |
Human CYP2B6 is closely regulated by constitutive androstane receptor (CAR/NR1I3) which can activate CYP2B6 expression upon ligand binding. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18303024 |
The CYP2B6 enzyme metabolizes commonly used therapeutics and also activates pro-drugs. The CAR directly binds to the distal enhancer element of the CYP2B6 promoter, which is essential in converging to its drug-sensing function onto promoter activity. However, this binding alone is not sufficient to activate the CYP2B6 promoter; the promoter requires EGR1 to enable CAR to activate the CYP2B6 promoter. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates 
binding
|
NR1I3 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123154 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15000748 |
The short heterodimer partner (shp), an orphan nuclear receptor that lacks a conventional dna binding domain, was initially identified by its interaction with car. We have examined the role of shp in car-mediated transactivation of the cyp2b gene. Coexpression of shp inhibited the transactivation of the cyp2b gene by car in cultured hepatoma cells and the p160 coactivator grip1 reversed the inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1I3 | up-regulates 
binding
|
RXRA |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104441 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12896978 |
Therefore, both car-rxr heterodimers and car monomers can contribute to the gene activating function of pbrems in car target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NR1I3
- 
- 