Summary

Name NR0B2
Full Name Nuclear receptor subfamily 0 group B member 2
Synonyms Orphan nuclear receptor SHP, Small heterodimer partner | SHP
Primary ID Q15466
Links - -
Type protein
Relations 25
Function Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR0B2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR1I3 0.527
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.512
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR1H2 0.475
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation THR 0.38
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR5A2 0.58
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NR0B2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding AR 0.427
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR1H3 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6PC1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ESR2 0.605
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation THRA 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PCK2 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR0B2 0.399
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding ESR1 0.63
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates activity img/direct_inhibition.png binding CEBPA 0.274
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ESRRG 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HNF4A 0.44
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR1I2 0.583
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR0B2 0.63
Publications: 1 Organism: Homo Sapiens