Summary

Name HERPUD1
Full Name Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Synonyms Methyl methanesulfonate (MMF)-inducible fragment protein 1 | HERP, KIAA0025, MIF1
Primary ID Q15011
Links - -
Type protein
Relations 5
Function Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png HERPUD1 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HERPUD1 0.592
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png relocalization HSPA5 0.423
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HERPUD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HERPUD1 0.323
Publications: 1 Organism: Homo Sapiens